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ALAS1

 
Wikipedia: ALAS1
aminolevulinate, delta-, synthase 1
Identifiers
Symbol ALAS1
Alt. Symbols ALAS3, ALAS
Entrez 211
HUGO 396
OMIM 125290
RefSeq NM_000688
UniProt P13196
Other data
EC number 2.3.1.37
Locus Chr. 3 p21

Delta-aminolevulinate synthase 1 also known as ALAS1 is a protein which in humans is encoded by the ALAS1 gene.[1][2] ALAS1 is an aminolevulinic acid synthase.

Delta-aminolevulinate synthase catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid. This nuclear-encoded mitochondrial enzyme is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by ALAS2.[2]

References

  1. ^ Bishop DF, Henderson AS, Astrin KH (June 1990). "Human delta-aminolevulinate synthase: assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome". Genomics 7 (2): 207–14. PMID 2347585. 
  2. ^ a b "Entrez Gene: Delta-aminolevulinate synthase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=211. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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