Library

Albiglutide

Share on Facebook Share on Twitter Email
Wikipedia on Answers.com:

Albiglutide

Top
Home > Library > Miscellaneous > Wikipedia

Albiglutide is a GLP-1 analog drug under investigation by GlaxoSmithKline for treatment of type 2 diabetes. It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin.

Albiglutide has a half-life of four to seven days, which is considerably longer than the other two GLP-1 analogs approved for market use, exenatide (Byetta) and liraglutide (Victoza).[1] [2] GLP-1 drugs are currently only available for subcutaneous administration on a daily basis, so a GLP-1 drug with a longer half-life is desirable. Such a drug would only need to be injected biweekly or weekly instead of daily, reducing the discomfort and inconvenience of GLP-1 administration considerably.

It has not yet been determined whether albiglutide is as effective an antidiabetic agent as GLP-1 drugs currently on the market, and final data remain to be published regarding the incidence of adverse effects related to the drug. To evaluate the efficacy and safety of the drug, albiglutide is undergoing eight Phase III clinical trials. Four of these trials should report useful data by end 2010.[3]

See also

exenatide (Byetta)
liraglutide (Victoza)
taspoglutide

References

  1. ^ Matthews JE, Stewart MW, De Boever EH, et al. (December 2008). "Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Albiglutide, a Long-Acting Glucagon-Like Peptide-1 Mimetic, in Patients with Type 2 Diabetes". J. Clin. Endocrinol. Metab. 93 (12): 4810–4817. doi:10.1210/jc.2008-1518. PMID 18812476. http://jcem.endojournals.org/cgi/pmidlookup?view=long&pmid=18812476. 
  2. ^ Baggio et al. (2008). "Glucagon-like Peptide-1 Analogs Other Than Exenatide". http://www.medscape.com/viewarticle/578304. 
  3. ^ "Phase III clinical trials of Albiglutide". http://clinicaltrials.gov/ct2/results?term=Albiglutide&phase=2. 
v · d · eOral anti-diabetic drugs and Insulin analogs (A10)
Insulin
Metformin# • Buformin‡ • Phenformin‡
Meglitinides/"glinides"
Exenatide • Liraglutide • Taspoglutide† • Albiglutide† • Lixisenatide
Analogs/other insulins
fast-acting (Insulin lispro • Insulin aspart • Insulin glulisine) • short-acting (Regular insulin) • long-acting (Insulin glargine • Insulin detemir • NPH insulin) • ultra-long-acting (Insulin degludec†) • inhalable Exubera‡
Other
Amylin analog
SGLT2 inhibitors
Other


Stub icon This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)

Post a question - any question - to the WikiAnswers community:

Copyrights:

Cite
Wikipedia on Answers.com This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article Albiglutide. Read more

Featured guides

» More

Mentioned in

Glucagon-like peptide-1 analog
Tolazamide
Gliquidone
Carbutamide
Taspoglutide
» More