Alclometasone

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Drug Info:

Alclometasone

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Brand names: Aclovate®

Chemical formula:



Alclometasone Dipropionate Topical ointment

What is this medicine?

ALCLOMETASONE (al kloe MET a sone) is a corticosteroid. It is used to treat skin problems that may cause itching, redness, and swelling.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•any type of active infection
•large areas of burned or damaged skin
•thinning of the skin
•an unusual or allergic reaction to alclometasone, corticosteroids, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

This medicine is for external use only. Do not take by mouth. Follow the directions on the prescription label. Wash your hands before and after use. Apply a thin film of medicine to the affected area. Do not cover with a bandage or dressing unless your doctor or health care professional tells you to. Do not use on healthy skin or over large areas of skin. Do not get this medicine in your eyes. If you do, rinse out with plenty of cool tap water. It is important not to use more medicine than prescribed. Do not use your medicine more often than directed. Do not use for more than 14 days.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this drug may be prescribed for children as young as 1 year of age for selected conditions, precautions do apply. If applying this medicine to the diaper area of a child, do not cover with tight-fitting diapers or plastic pants. This may increase the amount of medicine that passes through the skin and increase the risk of serious side effects.

Elderly patients are more likely to have damaged skin through aging, and this may increase side effects. This medicine should only be used for brief periods and infrequently in older patients.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Interactions are not expected. Do not use any other skin products without telling your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your symptoms do not get better within 2 weeks, or if you develop skin irritation. Tell your doctor or health care professional if you are exposed to anyone with measles or chickenpox, or if you develop sores or blisters that do not heal properly.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•lack of healing of the skin condition
•painful, red, pus filled blisters on the skin or in hair follicles
•severe burning and continued irritation of the skin
•thinning of the skin with easy bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•burning or irritation of the skin
•increased redness or scaling of the skin

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 2 and 30 degrees C (36 and 86 degrees F). Do not freeze. Throw away any unused medicine after the expiration date.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Alclometasone
Systematic (IUPAC) name
[7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
Clinical data
Trade names Aclovate
AHFS/Drugs.com monograph
MedlinePlus a604021
Pregnancy cat.  ?
Legal status Rx Only (US)
Routes topical
Identifiers
CAS number 66734-13-2 YesY
ATC code D07AB10 S01BA10
PubChem CID 5311000
DrugBank DB00240
ChemSpider 4470541 YesY
UNII 136H45TB7B YesY
KEGG D01820 YesY
ChEBI CHEBI:53776 YesY
ChEMBL CHEMBL1201361 N
Chemical data
Formula C28H37ClO7 
Mol. mass 521.042 g/mol
SMILES eMolecules & PubChem
 N (what is this?)  (verify)

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.

Alclometasone dipropionate marketed as Aclovate by GlaxoSmithKline.

Contents

Pharmacology

Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications

Alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including:

Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

Contraindications

  • hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
  • cutaneous tuberculosis
  • chicken pox
  • perioral dermatitis
  • acne
  • rosacea
  • open wounds
  • trophic ulcers
  • viral infection of skin
  • skin manifestations of syphilis

Side effects

Adverse reactions (sometimes, less than 1-2% cases) include:

  • burning
  • itching
  • erythema
  • skin reddening
  • xerodermia
  • skin irritation
  • acne
  • hypopigmentation
  • prickly heat
  • folliculitis
  • white atrophy
  • hypertrichosis
  • reinfection of skin

How supplied

Alclometasone as Aclovate is supplied in:

  • Cream; Topical; 0.05%
  • Ointment; Topical; 0.05%



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