Alcohol oxidase
Oxford Dictionary of Biochemistry:
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alcohol oxidase
or methanol oxidase abbr.: MOX;
EC 1.1.3.13; a flavoprotein (FAD) enzyme that catalyses the oxidation by dioxygen of a primary alcohol to the corresponding aldehyde. It is important in methylotrophic yeasts, in which it is the first enzyme in the pathway for utilization of methanol, converting this to formaldehyde, thence to CO2.
EC 1.1.3.13; a flavoprotein (FAD) enzyme that catalyses the oxidation by dioxygen of a primary alcohol to the corresponding aldehyde. It is important in methylotrophic yeasts, in which it is the first enzyme in the pathway for utilization of methanol, converting this to formaldehyde, thence to CO2.
| alcohol dehydrogenase, alcohol, alcaptonuria | |
| alcoholic fermentation, alcoholism, alcoholysis |
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Alcohol oxidase
| alcohol oxidase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 1.1.3.13 | ||||||
| CAS number | 9073-63-6 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, an alcohol oxidase (EC 1.1.3.13) is an enzyme that catalyzes the chemical reaction
- a primary alcohol + O2
an aldehyde + H2O2
Thus, the two substrates of this enzyme are primary alcohol and O2, whereas its two products are aldehyde and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is alcohol:oxygen oxidoreductase. This enzyme is also called ethanol oxidase. It employs one cofactor, FAD.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1AHU, 1AHV, 1AHZ, 1VAO, 1W1J, 1W1K, 1W1L, 1W1M, and 2VAO.
References
- Janssen FW, Ruelius HW (1968). "Alcohol oxidase, a flavoprotein from several Basidiomycetes species Crystallization by fractional precipitation with polyethylene glycol". Biochim. Biophys. Acta. 151 (2): 330–42. PMID 5636370.
- Nishida A, Ishihara T and Hiroi T (1987). "Studies on enzymes related to lignan biodegradation". Baiomasu Henkan Keikaku Kenkyu Hokoku: 38–59.
- Suye S (1997). "Purification and properties of alcohol oxidase from Candida methanosorbosa M-2003". Curr. Microbiol. 34 (6): 374–7. doi:10.1007/s002849900198. PMID 9142745.
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