ALD-52
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ALD-52
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| Systematic (IUPAC) name | |
| 1-Acetyl-N,N-diethyllysergamide | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | ? |
| Chemical data | |
| Formula | C22H27N3O2 |
| Mol. mass | 365.469 g/mol |
| Synonyms | ALD, N-acetyl-LSD, Acetyl lysergic acid diethylamide, d-acetyl lysergic acid diethylamide, d-acetyldiethyllysergamide |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | hepatic |
| Half life | ? |
| Excretion | renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Analogue of LSD and therefore controlled in the |
| Routes | Oral |
ALD-52 or N-acetyl-LSD, is a chemical analogue of LSD (Lysergic Acid Diethylamide). It was originally discovered by Albert Hofmann but was not widely studied until the rise in popularity of psychedelics in the 1960s.
Effects
In TiHKAL, Shulgin touches briefly on ALD-52 in entry 26, LSD. His writings are vague, second hand accounts, saying doses in the 50-175µg range have resulted in various conclusions. One found that there was less visual distortion than with LSD and it seems to produce less anxiety and was somewhat less potent than LSD. Another report claimed it was more effective in increasing blood pressure. Yet another could not tell them apart.
It has the same characteristics as LSD, but supposedly "without the anxiety, tenseness, and other problems inherent to it".
Dangers
In The Hallucinogens by Hoffer and Osmond (1967), ALD-52 (D,L-Acetyllysergic acid diethylamide) is listed as having a lower (approximately 1/5) intravenous toxicity (in rabbits), a lower (approximately 1/8) pyretogenic effect, an equal psychological effect in man, and double the antiserotonin effect as compared with LSD.
History
It is possible ALD-52 was the active chemical in the "Orange Sunshine" acid available during the Summer of Love. [citation needed]
One of the underground chemist's labs reportedly made ALD-52, and was shut down by the police, and the indivduals involved were arrested and prosecuted. This resulted in the first drug analogue trial, where the chemists claimed they did nothing wrong producing ALD-52, because LSD was the illicit drug. However, as the prosecution claimed, there were problems with such rationale, firstly, ALD-52 undergoes hydrolysis readily to LSD, and secondly the synthesis of ALD-52 required LSD (this was based on the methods available in the scientific literature at the time). [citation needed]
Sources
| Psychedelic lysergamides |
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AL-LAD • ALD-52 • BU-LAD • CYP-LAD • Diallyllysergamide • DAM-57 • Ergonovine • ETH-LAD • LAE-32 • LSD • LPD-824 • LSM-775 • D-Lysergic acid N-(α-hydroxyethyl)amide • Methylergonovine • MLD-41 • PARGY-LAD • PRO-LAD |
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