Alfacalcidol
Oxford A-Z of Medicinal Drugs:
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alfacalcidol
A derivative of vitamin D used to prevent and treat the bone disease that may occur in kidney dialysis patients. Alfacalcidol is available as capsules, oral drops, or a solution for intravenous injection on prescription only.
Side effects, precautions, and interactions with other drugs:
see vitamin D.
Proprietary preparation:
One Alpha.
| alendronic acid, alemtuzumab, aldesleukin | |
| alfentanil, alfuzosin hydrochloride, alginic acid |
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Alfacalcidol
| Alfacalcidol | |
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(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol |
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Other names
Alphacalcidol; 1-Hydroxycholecalciferol |
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| Identifiers | |
| CAS number | 41294-56-8  |
| PubChem | 5282181 |
| ChemSpider | 4445376 |
| UNII | URQ2517572 |
| DrugBank | DB01436 |
| KEGG | D01518 |
| ChEMBL | CHEMBL32540  |
| ATC code | A11 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C27H44O2 |
| Molar mass | 400.64 g/mol |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Alfacalcidol (or 1-hydroxycholecalciferol) is an analogue of vitamin D. Used for supplementation in humans and as a poultry feed additive.
It has less of an effect on calcium metabolism than calcitriol,[1] while having more potent effects on parathyroid hormone levels[2] and immune system, including regulatory T cells.[3]
Considered to be a more useful form of vitamin D supplementation, mostly due to much longer half-life and lower kidney load.[4]
Used as a poultry feed additive, it prevents tibial dyschondroplasia and increases phytate bioavailability.[5][original research?]
References
- ^ Biological effects of various regimes of 25-hydroxyvitamin D3 (calcidiol) administration on bone mineral metabolism in postmenopausal women, Clin Cases Miner Bone Metab. 2009 May–Aug; 6(2): 169–173; [1]
- ^ Oral calcitriol versus oral alfacalcidol for the treatment of secondary hyperparathyroidism in patients receiving hemodialysis: a randomized, crossover trial, Can J ,Clin Pharmacol Vol 15 (1) Winter 2008:e36 -e43; January 9, 2008; [2]
- ^ Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue disease, Autoimmunity Reviews, August 2010;
- ^ Superiority of alfacalcidol compared to vitamin D plus calcium in lumbar bone mineral density in postmenopausal osteoporosis, Rheumatol Int. 2006 Mar;26(5):445-53. Epub 2005 Nov 10; [3]
- ^ VDI Product Data
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