Alfentanil
Drug Info:
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Alfentanil
Brand names: Alfenta®
Chemical formula:
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
Oxford A-Z of Medicinal Drugs:
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alfentanil
A potent opioid with a very rapid onset of action. It is used for pain relief during short surgical operations and to relieve pain and depress breathing in patients on ventilators in intensive care. Alfentanil is a controlled drug; it is available as an intravenous infusion or injection.
Side effects and precautions:
see morphine.
Interactions with other drugs:
see opioids.
Proprietary preparation:
Rapifen.
| alfacalcidol, alendronic acid, alemtuzumab | |
| alfuzosin hydrochloride, alginic acid, alglucosidase alfa |
Saunders Veterinary Dictionary:
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alfentanil
An opioid analgesic; a derivative of fentanyl with lower potency but more rapid action.
Wikipedia on Answers.com:
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Alfentanil
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| Systematic (IUPAC) name | |
| N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide | |
| Clinical data | |
| Trade names | Alfenta |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| MedlinePlus | a601130 |
| Pregnancy cat. | ? |
| Legal status | ? (UK) Schedule II (US) |
| Routes | Intravenous |
| Pharmacokinetic data | |
| Bioavailability | 100% |
| Protein binding | 92% |
| Metabolism | Hepatic |
| Half-life | 90–111 minutes |
| Identifiers | |
| CAS number | 71195-58-9  |
| ATC code | N01AH02 |
| PubChem | CID 51263 |
| DrugBank | DB00802 |
| ChemSpider | 46451 |
| UNII | 1N74HM2BS7 |
| KEGG | D07122 |
| ChEBI | CHEBI:2569 |
| ChEMBL | CHEMBL634 |
| Chemical data | |
| Formula | C21H32N6O3 |
| Mol. mass | 416.517 g/mol |
| SMILES | eMolecules & PubChem |
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| Physical data | |
| Melt. point | 140.8 °C (285 °F) |
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Alfentanil (R-39209, trade name Alfenta, Rapifen in Australia) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with around 1/4 the potency of fentanyl and around 1/3 of the duration of action, but with an onset of effects 4x faster than fentanyl.[1] It is an OP3 mu-agonist.
While alfentanil tends to cause fewer cardiovascular complications than other similar drugs such as fentanyl and remifentanil, it tends to give stronger respiratory depression and so requires careful monitoring of breathing and vital signs. Alfentanil is administered by the parenteral (injected) route for fast onset of effects and precise control of dosage.
Alfentanil is a restricted drug which is classified as Schedule II in the USA, according to the U.S. DEA website.[2]
Alfentanil was discovered at Janssen Pharmaceutica in 1976.
References
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Copyrights:
Oxford A-Z of Medicinal Drugs
Market University Press. © 2000, 2003, 2010 An A-Z of Medicinal Drugs. All rights reserved.
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Saunders Veterinary Dictionary
Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.
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