Alkaline tide
Oxford Dictionary of Biochemistry:
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alkaline tide
the slight increase in plasma and urine pH that occurs after meals. It is believed to be due to withdrawal of hydrogen ions from the blood during the formation of gastric HCl.
| alkaline phosphatase, alkaline lysis method, alkaline earth | |
| alkaloid, alkalosis, alkane |
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Alkaline tide
Alkaline tide refers to a condition, normally encountered after eating a meal, when stomach acid is released into the stomach causing a temporary increase in pH of the blood.
During hydrochloric acid excretion in the stomach, the gastric parietal cells extract chloride anions, carbon dioxide, water and sodium cations from the blood plasma and in turn release bicarbonate back into the plasma after the hydrochloric acid is formed from carbon dioxide and water constituents. This is to maintain the plasma's electrical balance, as the chloride anions have been extracted. The bicarbonate content causes the venous blood leaving the stomach to be more alkaline than the arterial blood delivered to it.
Post-prandial (i.e., after a meal) alkaline tide lasts until the acids in food absorbed in the small intestine reunite with the bicarbonate that was produced when the food was in the stomach. Thus, alkaline tide is self-limited and normally lasts less than two hours.
Post-prandial alkaline tide has also been shown to be a causative agent of calcium oxalate urinary stones in cats,[1] and potentially in other species[2]
A more pronounced alkaline tide results from vomiting, which stimulates hyperactivity of gastric parietal cells to replace lost stomach acid. Thus, protracted vomiting can result in metabolic alkalosis.[citation needed]
References
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This article includes a list of references, related reading or external links, but its sources remain unclear because it lacks inline citations. Please improve this article by introducing more precise citations. (July 2010) |
- Gennari, F. John (2005). Acid-base disorders and their treatment. Informa Health Care. p. 217. ISBN 0-8247-5915-X. http://books.google.com/books?id=bZF8zc0ue6IC&pg=PA217&dq=%22Alkaline+tide%22&hl=en&ei=P601TOPGDMX_lgeZudzVBw&sa=X&oi=book_result&ct=result&resnum=4&ved=0CDwQ6AEwAw#v=onepage&q=%22Alkaline%20tide%22&f=false.
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