Alkenylglycerophosphocholine hydrolase
Oxford Dictionary of Biochemistry:
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alkenylglycerophosphocholine hydrolase
EC 3.3.2.2; other name: lysoplasmalogenase; a phospholipase involved in the turnover of plasmalogens. It catalyses the hydrolysis of 1-(1-alkenyl)-sn-glycero-3-phosphocholine to an aldehyde and sn-glycero-3-phosphocholine.
| alkenyl, alkatrienyl, alkatriene | |
| alkenylglycerophosphoethanolamine hydrolase, alkyl, alkylating agent |
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Alkenylglycerophosphocholine hydrolase
| alkenylglycerophosphocholine hydrolase | |||||||
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| Identifiers | |||||||
| EC number | 3.3.2.2 | ||||||
| CAS number | 37288-65-6 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, an alkenylglycerophosphocholine hydrolase (EC 3.3.2.2) is an enzyme that catalyzes the chemical reaction
- 1-(1-alkenyl)-sn-glycero-3-phosphocholine + H2O
an aldehyde + sn-glycero-3-phosphocholine
Thus, the two substrates of this enzyme are 1-(1-alkenyl)-sn-glycero-3-phosphocholine and H2O, whereas its two products are aldehyde and sn-glycero-3-phosphocholine.
This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is 1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase. This enzyme is also called lysoplasmalogenase. This enzyme participates in ether lipid metabolism.
References
- Arthur G, Page L, Mock T, Choy PC (1986). "The catabolism of plasmenylcholine in the guinea pig heart". Biochem. J. 236 (2): 475–80. PMC 1146864. PMID 3753461. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1146864.
- Ellingson JS and Lands WEM (1968). "Phospholipid reactivation of plasmalogen metabolism". Lipids 3 (2): 111–120. doi:10.1007/BF02531727. PMID 17805898.
- Warner HR and Lands WEM (1961). "The metabolism of plasmalogen: enzymatic hydrolysis of the vinyl ether" (PDF). J. Biol. Chem. 236 (9): 2404–2409. PMID 13783189. http://www.jbc.org/content/236/9/2404.full.pdf.
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Oxford Dictionary of Biochemistry
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