Allobarbital

Allobarbital

Systematic (IUPAC) name
5,5-diprop-2-enyl-1,3-diazinane-2,4,6-trione
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	52-43-7
ATC code	N05CA21
PubChem	CID 5842
ChemSpider	5635 Y
UNII	8NT43GG2HA Y
KEGG	D02817 Y
ChEMBL	CHEMBL267719 Y
Synonyms	5,5-Diallylbarbituric acid, Allobarbital
Chemical data
Formula	C10H12N2O3
Mol. mass	208.214 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C10H12N2O3/c1-3-5-10(6-4-2)7(13)11-9(15)12-8(10)14/h3-4H,1-2,5-6H2,(H2,11,12,13,14,15) Y Key:FDQGNLOWMMVRQL-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Allobarbital, also known as allobarbitone and branded as Cibalgine or Dial-Ciba (in combination with ethyl carbamate), is a barbiturate derivative invented in 1912 by Ernst Preiswerk and Ernst Grether working for CIBA. It was used primarily as an anticonvulsant ^[1] although it has now largely been replaced by newer drugs with improved safety profiles. Other uses for allobarbital included as an adjutant to boost the activity of analgesic drugs, and use in the treatment of insomnia and anxiety.

Allobarbital was never particularly widely used compared to better known barbiturates such as phenobarbital and secobarbital, although it saw more use in some European countries such as Bulgaria and Slovakia,^[2] and is still used in for example Poland, but only as compound^[3].

References

1. ^ Chocholova L, Radil-Weiss T. Effect of allobarbital on focal epilepsy in rats. Physiologia Bohemoslovaca. 1971;20(4):325-34.
2. ^ Getova D, Georgiev V. GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists. Acta Physiologica et Pharmacologica Bulgarica. 1987;13(3):43-50.
3. ^ http://www.domzdrowia.pl/29439,apteczka-babuni-krople-zoladkowe-krople-20-g.html