Allylglycine
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Allylglycine
| Allylglycine | |
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2-Aminopent-4-enoic acid |
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| Identifiers | |
| CAS number | 7685-44-1 |
| PubChem | 14044 |
| ChemSpider | 13425  |
| Jmol-3D images | Image 1 Image 2 |
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| Properties | |
| Molecular formula | C5H9NO2 |
| Molar mass | 115.13 g/mol |
| Melting point |
265 °C, 538 K, 509 °F |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Allylglycine is a glycine derivative. It is an inhibitor of the enzyme glutamate decarboxylase.[1] Inhibition of glutamate decarboxylase blocks GABA biosynthesis, leading to lower levels of the neurotransmitter.[2] It is used to induce convulsions in animals in scientific studies.[citation needed]
References
- ^ Abshire VM, Hankins KD, Roehr KE, DiMicco JA (November 1988). "Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate". Neuropharmacology 27 (11): 1171–7. doi:10.1016/0028-3908(88)90013-5. PMID 3205383.
- ^ Sajdyk T, Johnson P, Fitz S, Shekhar A (August 2008). "Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior". J. Psychopharmacol. (Oxford) 22 (6): 633–41. doi:10.1177/0269881107082902. PMID 18308797. http://jop.sagepub.com/cgi/pmidlookup?view=long&pmid=18308797.
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