alpha-Mannosidase is an enzyme involved in the cleavage of the alpha form of mannose. It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development[1].
Pathology
A deficiency can lead to alpha-mannosidosis[2].
References
- ^ Vlahopoulos S, Gritzapis AD, Perez SA, Cacoullos N, Papamichail M, Baxevanis CN. Mannose addition by yeast Pichia Pastoris on recombinant HER-2 protein inhibits recognition by the monoclonal antibody herceptin. Vaccine. 2009 Jun 8. [Epub ahead of print]PMID: 19520203
- ^ Malm D, Nilssen Ø. Alpha-mannosidosis. Orphanet J Rare Dis. 2008 Jul 23;3:21. Review. PMID: 18651971
External links
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