Alpha-methylacyl-CoA racemase

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In enzymology, an alpha-methylacyl-CoA racemase (EC 5.1.99.4) is an enzyme that catalyzes the chemical reaction

(2S)-2-methylacyl-CoA (2R)-2-methylacyl-CoA

Hence, this enzyme has one substrate, (2S)-2-methylacyl-CoA, and one product, (2R)-2-methylacyl-CoA.

This enzyme belongs to the family of isomerases, to be specific those racemases and epimerases acting on other compounds. The systematic name of this enzyme class is 2-methylacyl-CoA 2-epimerase.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1X74, 2G04, 2GCE, 2GCI, 2GD0, 2GD2, and 2GD6.

References

• Schmitz W, Fingerhut R, Conzelmann E (1994). "Purification and properties of an alpha-methylacyl-CoA racemase from rat liver". Eur. J. Biochem. 222 (2): 313–23. doi:10.1111/j.1432-1033.1994.tb18870.x. PMID 8020470.