AM-2201

AM-2201

Systematic (IUPAC) name
1-[(5-fluoropentyl)-1H-indol-3-yl]-(naphthalen-1-yl)methanone
Clinical data
Pregnancy cat.	?
Legal status	Temporary Class Drug (NZ)
Identifiers
CAS number	335161-24-5 Y
ATC code	?
ChemSpider	24751884 Y
Chemical data
Formula	C24H22FNO
Mol. mass	359.435 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C24H22FNO/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,15-16H2 Y Key:ALQFAGFPQCBPED-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) is a research chemical that acts as a potent but unselective agonist for the cannabinoid receptor CB₁, with a K_i of 1.0nM at CB₁ and 2.6nM at CB₂.^[1] Reputed recreational use of AM-2201 in the United States has led to it being specifically listed in a proposed 2011 amendment to the Controlled Substances Act, aiming to add a number of synthetic drugs into Schedule I.^[2] There have been anecdotal reports of individuals experiencing panic attacks and vomiting, at doses as small as 2 milligrams. As the dosage is much smaller than most other synthetic cannabinoids, users may accidentally dose too much. Convulsions have been reported at doses exceeding 10 milligrams.^[3] Caution should be taken if using this substance as it is active at doses as small as 500 µg (micrograms), has a very steep dose-response curve, and tolerance builds up quickly to the effects. As of November 2011, there have been no reports of death associated with the drug. The toxicity of AM-2201 is still a matter of debate and there may be long term side effects.

See also

• AM-2233
• AM-694
• AM-1235
• AM-2232
• JWH-018

References

1. ^ WO patent 0128557, Makriyannis A, Deng H, "Cannabimimetic indole derivatives", granted 2001-06-07 
2. ^ Synthetic Drug Control Act of 2011
3. ^ http://www.erowid.org/experiences/exp.php?ID=89294

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