AM-855
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AM-855
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| Systematic (IUPAC) name | |
| (4aR,12bR)-8-hexyl-2,5,5-trimethyl-1,4,4a,8,9,10,11,12b-octahydronaphtho[3,2-c]isochromen-12-ol | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| ATC code | ? |
| PubChem | CID 10091328 |
| ChemSpider | 8266865  |
| ChEMBL | CHEMBL303479 |
| Chemical data | |
| Formula | C26H38O2 |
| Mol. mass | 382.577 g/mol |
| SMILES | eMolecules & PubChem |
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AM-855 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8Tetrahydrocannabinol with a conformationally restricted side chain which has been bound into a fourth ring fused to the aromatic A-ring of the cannabinoid skeleton. AM-855 is an agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 22.3nM at CB1 and 58.6nM at CB2.[1]
References
- ^ Khanolkara, Atmaram D.; Dai Lua, Pusheng Fana, Xiaoyu Tiana and Alexandros Makriyannis (August 1999). "Novel conformationally restricted tetracyclic analogs of Δ8-tetrahydrocannabinol". Bioorganic & Medicinal Chemistry Letters 9 (15): 2119–24. doi:10.1016/S0960-894X(99)00355-8. PMID 10465529.
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