Amcinonide

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amcinonide

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A glucocorticoid used for topical application in the treatment of corticosteroid-responsive dermatoses.

Amcinonide

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Amcinonide

Systematic (IUPAC) name
2-[(1S,2S,4R,8S,9S,11S,12R,13S)-12'-fluoro-11'-hydroxy-9',13'-dimethyl-16'-oxo-5',7'-dioxaspiro[cyclopentane-1,6'-pentacyclo[10.8.0.0^2,9.0^4,8.0^13,18]icosane]-14',17'-dien-8'-yl]-2-oxoethyl acetate
Clinical data
Trade names	Cyclocort
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	C (US)
Legal status	℞-only (US)
Routes	Topical
Identifiers
CAS number	51022-69-6^Y
ATC code	D07AC11
PubChem	CID 443958
DrugBank	DB00288
ChemSpider	392009^Y
UNII	423W026MA9^Y
KEGG	D01387^Y
ChEBI	CHEBI:31199^Y
ChEMBL	CHEMBL1200732^N
Chemical data
Formula	C₂₈H₃₅F O₇
Mol. mass	502.572 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1^Y Key:ILKJAFIWWBXGDU-MOGDOJJUSA-N^Y
N (what is this?) (verify)

Amcinonide (trade name Cyclocort) is a topical glucocorticoid used to treat itching, redness and swelling associated with several dermatologic conditions such as atopic dermatitis and allergic contact dermatitis.^[1]^[2]

References

^ Drugs.com: Amcinonide topical
^ Bickers, D. R. (1984). "A comparative study of amcinonide and halcinonide in the treatment of eczematous dermatitis". Cutis; cutaneous medicine for the practitioner 34 (2): 190–194. PMID 6383735. edit

Corticosteroids – glucocorticoids and mineralocorticoids (H02)
(also A07EA, C05AA, D07, D10AA, R01AD, R03BA, S01BA, S02B, and S03B)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)

Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)

Pregnene	CORTISONE

Pregnenedione (+20-one)	HYDROCORTISONE/CORTISOL^# (Hydrocortisone aceponate Hydrocortisone buteprate Hydrocortisone butyrate) Budesonide Ciclesonide Deflazacort Medrysone Tixocortol HALOGENATED AT 6: Cloprednol HALOGENATED, WITH FG AT 16: Halcinonide

Pregnadiene (+1-ene)	Rimexolone HALOGENATED, WITH FG AT 16: Flunisolide Triamcinolone Amcinonide Fluocinolone acetonide (Fluocinonide)

Pregnadienediol (+21-hydroxy)	Prednisone (Meprednisone) HALOGENATED AT 9: Fluorometholone HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone Diflucortolone Fluocortin) Desoximetasone

Pregnadienetriol (+11-hydroxy)	Prednisolone^# (Methylprednisolone Methylprednisolone aceponate Prednicarbate Prednylidene) Desonide HALOGENATED: Fluprednisolone (Difluprednate Fluperolone) HALOGENATED, WITH FG AT 16: Dexamethasone^# Betamethasone (Clobetasol Clobetasone Diflorasone Halometasone Ulobetasol) Beclometasone Paramethasone Alclometasone Fluclorolone acetonide Flumetasone Fluprednidene

Pregnatriene (+2-ene)	Cortivazol

Androstene	HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate Fluticasone furoate)

Other/ungrouped	HALOGENATED: Loteprednol HALOGENATED, WITH FG AT 16: Fludroxycortide Formocortal Mometasone furoate

Aldosterone antagonists

Synthesis modifiers

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)

Glucocorticoids

Receptor

Agonists: Acrocinonide
Alclometasone
Amcinafal
Amcinafide
Amcinonide
Amebucort
Amelometasone
Amicinonide
Anecortave
Beclometasone
Beclometasone dipropionate
Betamethasone
Betamethasone acibutate
Betamethasone dipropionate
Budesonide
Butixocort
Chloroprednisone
Ciclesonide
Cicortonide
Ciprocinonide
Clobetasol
Clobetasol propionate
Clobetasone
Clocortolone
Cloprednol
Cloticasone
Cormetasone
Corticosterone
Cortisone
Cortisuzol
Cortivazol
Cortodoxone
Deflazacort
Deoxycorticosterone
Deprodone
Descinolone
Desonide
Desoximetasone
Desoxycortone
Dexbudesonide
Dexamethasone
Dexamethasone acefurate
Dexamethasone cipecilate
Dexamethasone isonicotinate
Dichlorisone
Diflorasone
Difluocortolone
Difluocortolone valerate
Difluprednate
Domoprednate
Doxibetasol
Drocinonide
Etiprednol dicloacetate
Fluazacort
Fluclorolone
Fluclorolone/Flucloronide
Fludrocortisone
Fludroxycortide
Flumoxonide
Flumetasone
Flunisolide
Fluocinolone
Fluocinolone acetonide
Fluocinonide
Fluocortin
Fluocortolone
Fluorometholone
Fluperolone
Fluperolone acetate
Fluprednidene
Fluprednidene acetate
Fluprednisolone
Fluticasone
Fluticasone furoate
Fluticasone propionate
Formocortal
Halcinonide
Halocortolone
Halometasone
Halopredone
Hydrocortamate
Hydrocortisone/Cortisol
Hydrocortisone aceponate
Hydrocortisone buteprate
Hydrocortisone-17-butyrate
Hydrocortisone-21-butyrate
Icometasone enbutate
Isoflupredone
Isoprednidene
Itrocinonide
Locicortolone dicibate
Loteprednol
Mazipredone
Meclorisone
Medrysone
Meprednisone
Methylprednisolone
Methylprednisolone aceponate
Methylprednisolone suleptanate
Mometasone
Mometasone furoate
Naflocort
Nicocortonide
Nivacortol
Oxisopred
Paramethasone
Prednazate
Prednazoline
Prednicarbate
Prednimustine
Prednisolamate
Prednisolone
Prednisolone steaglate
Prednisone
Prednylidene
Procinonide
Resocortol
Rimexolone
Rofleponide
Timobesone
Tipredane
Tixocortol
Tixocortol pivalate
Tralonide
Triamcinolone
Triamcinolone acetonide
Triamcinolone benetonide
Triamcinolone furetonide
Triamcinolone hexacetonide
Triclonide
Ulobetasol/Halobetasol

Mixed (SEGRAs): Mapracorat

Antagonists: Algepristone
Asoprisinil
17-Hydroxyprogesterone
Ketoconazole
Lilopristone
Mifepristone
Onapristone
Org 34850
PCN
Pregnenolone
Progesterone
Telapristone
Toripristone
Ulipristal acetate

Enzyme
(inhibitors)

20,22-Desmolase	22-ABC 3,3′-Dimethoxybenzidine 3-Methoxybenzidine Aminoglutethimide Cyanoketone Danazol Etomidate Mitotane Trilostane

17α-Hydroxylase, 17,20-Lyase	22-ABC 22-Oxime Abiraterone Bifonazole Clotrimazole Cyanoketone Cyproterone Danazol Desogestrel Econazole Galeterone Gestrinone Isoconazole Ketoconazole L-39 Levonorgestrel Liarozole LY-207,320 MDL-27,302 Miconazole Mifepristone Norethisterone Orteronel Pioglitazone Rosiglitazone Spironolactone Stanozolol SU-10,603 Tioconazole TGF-β Troglitazone VN/87-1 YM116

3β-HSD	4-MA Azastene Cyanoketone Danazol Desogestrel Epostane Genistein Gestrinone Levonorgestrel Medroxyprogesterone Medroxyprogesterone acetate Metyrapone Norethisterone Oxymetholone Pioglitazone Rosiglitazone Trilostane Troglitazone

21-Hydroxylase	Aminoglutethimide Amphenone B Bifonazole Clotrimazole Diazepam Econazole Genistein Isoconazole Ketoconazole Metyrapone Miconazole Midazolam Tioconazole

Other

Endogenous	Glucocorticoids: Corticosterone Cortisone Cortodoxone/Deoxycortisol Hydrocortisone/Cortisol Antiglucocorticoids: 17-Hydroxyprogesterone Deoxycorticosterone Pregnenolone Progesterone Precursors: Cholesterol 22R-Hydroxycholesterol 20α,22R-Dihydroxycholesterol Pregnenolone 17-Hydroxypregnenolone 17-Hydroxyprogesterone Progesterone Deoxycorticosterone

Indirect	ACTH/Corticotropin CRH DHEA DHEA sulfate Plasma proteins (Transcortin, Albumin)

Procedures	Adrenalectomy Hypophysectomy

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