Amino acid transporter
Oxford Dictionary of Biochemistry:
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amino acid transporter
abbr.: AAT; any of numerous membrane proteins involved in amino acid transport into cells or into membranous organelles such as mitochondria, chloroplasts, and vesicles. The human genome contains 46 genes for AATs, that of Arabidopsis has 53, and that of yeast 24. AATs fall into five superfamilies: amino acid-polyamine-choline (in bacteria, yeasts, plants, and animals); sodium-dicarboxylate symporter (only in animals); neurotransmitter (only in animals), amino acid transfer; and AATs within the major facilitator superfamily. These proteins are presumed to contain 10, 12, or 14 transmembrane segments. Mitochondrial AATs are presumed to contain six transmembrane segments.
| amino acid index, amino acid exchange matrix, amino acid | |
| amino acid-tRNA ligase, amino aciduria, amino alcohol |
Wikipedia on Answers.com:
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Amino acid transporter
| Transmembrane amino acid transporter protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Aa_trans | ||||||||
| Pfam | PF01490 | ||||||||
| InterPro | IPR013057 | ||||||||
| TCDB | 2.A.18 | ||||||||
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An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.
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Contents
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Solute carrier family examples
- (1) high affinity glutamate and neutral amino acid transporter[1]
- (3) heavy subunits of heteromeric amino acid transporters[2]
- (7) cationic amino acid transporter/glycoprotein-associated[3]
- (15) proton oligopeptide cotransporter[4]
- (17) vesicular glutamate transporter[5]
- (18) vesicular amine transporter[6]
- (25) some mitochondrial carriers[7]
- (26) multifunctional anion exchanger[8]
- (32) vesicular inhibitory amino acid transporter[9]
- (36) proton-coupled amino acid transporter[10]
- (38) System A & N, sodium-coupled neutral amino acid transporter[11]
VIAAT
Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles.[12]
Human proteins containing this domain
ATA2; SLC32A1; SLC36A1; SLC36A2; SLC36A3; SLC36A4; SLC38A1; SLC38A2; SLC38A3; SLC38A4; SLC38A5; SLC38A6;
References
- ^ Kanai Y, Hediger MA (2004). "The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects". Pflugers Arch 447 (5): 469–479. doi:10.1007/s00424-003-1146-4. PMID 14530974.
- ^ Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflugers Arch 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID 14770309.
- ^ Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters". Pflugers Arch 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310.
- ^ Daniel H, Kottra G (2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". Pflugers Arch 447 (5): 610–618. doi:10.1007/s00424-003-1101-4. PMID 12905028.
- ^ Reimer RJ, Edwards RH (2004). "Organic anion transport is the primary function of the SLC17/type I phosphate transporter family". Pflugers Arch 447 (5): 629–635. doi:10.1007/s00424-003-1087-y. PMID 12811560.
- ^ Eiden LE, Schafer MK, Weihe E, Schutz B (2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflugers Arch 447 (5): 636–640. doi:10.1007/s00424-003-1100-5. PMID 12827358.
- ^ Palmieri F (2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflugers Arch 447 (5): 689–709. doi:10.1007/s00424-003-1099-7. PMID 14598172.
- ^ Mount DB, Romero MF (2004). "The SLC26 gene family of multifunctional anion exchangers". Pflugers Arch 447 (5): 710–721. doi:10.1007/s00424-003-1090-3. PMID 12759755.
- ^ Gasnier B (2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflugers Arch 447 (5): 752–755. doi:10.1007/s00424-003-1091-2. PMID 12750892.
- ^ Boll M, Daniel H, Gasnier B (2004). "The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family". Pflugers Arch 447 (5): 776–779. doi:10.1007/s00424-003-1073-4. PMID 12748860.
- ^ Mackenzie B, Erickson JD (2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family". Pflugers Arch 447 (5): 784–795. doi:10.1007/s00424-003-1117-9. PMID 12845534.
- ^ [Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in {alpha}TC6 Cells, Mouse Clonal {alpha}-Cells, and {alpha}-Cells of Islets of Langerhans] Diabetes 52:2066-2074, 2003
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