any member of a group of broad-spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. An isolated form of deafness is induced by aminoglycosides in persons who carry one of two point mutations in the mtDNA for 12S rRNA.