aminopterin
American Heritage Dictionary:
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am·i·nop·ter·in
(ăm'ə-nŏp'tər-ĭn) 
n.
A folic acid antagonist, C19H20N8O5, used as an antineoplastic agent. It has been mainly replaced by methotrexate.
n.
A folic acid antagonist, C19H20N8O5, used as an antineoplastic agent. It has been mainly replaced by methotrexate.
[AMINO- + pterin, a chemical compound derived from , a compound first identified in butterflies' wings (from Greek pteron, wing).]
Oxford Dictionary of Biochemistry:
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aminopterin
4-aminofolic acid; a potent inhibitor of dihydrofolate reductase (Ki < 10−9 M). It is used as an antineoplastic agent in the treatment of acute leukemia and choriocarcinoma. Aminopterin blocks nucleotide biosynthesis and thus also DNA biosynthesis, and has a similar action to amethopterin. It is a component of HAT, a selective medium used in tissue culture.
| aminopeptidase, aminolysis, aminoglycoside phosphotransferase | |
| aminotransferase, amitosis, ammonium |
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American Heritage Dictionary
The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved.
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