Amiphenazole
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Amiphenazole
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| Systematic (IUPAC) name | |
| 5-phenyl-1,3-thiazole-2,4-diamine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 490-55-1 |
| ATC code | None |
| PubChem | CID 10275 |
| ChemSpider | 9855  |
| UNII | 7ZJ8PWY0XD |
| Chemical data | |
| Formula | C9H9N3S |
| Mol. mass | 191.253 g/mol |
| SMILES | eMolecules & PubChem |
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Amiphenazole (Daptazile) is a respiratory stimulant traditionally used as an antidote for barbiturate or opiate overdose, usually in combination with bemegride,[1][2] as well as poisoning from other sedative drugs[3][4] and treatment of respiratory failure from other causes.[5] It was considered particularly useful as it could counteract the sedation and respiratory depression produced by morphine but with less effect on analgesia.[6][7] It is still rarely used in medicine in some countries, although it has largely been replaced by more effective respiratory stimulants such as doxapram and specific opioid antagonists such as naloxone.[8][9]
References
- ^ Worlock A. Barbiturate poisoning treated with amiphenazole and bemegride. British Medical Journal. 1956 Nov 10;2(5001):1099-101. PMID 13364395
- ^ Mears GW. Massive doses of bemegride and amiphenazole in treatment of barbiturate poisoning. British Medical Journal. 1958 Mar 29;1(5073):757-8. PMID 13510792
- ^ Dotevall G, Herner B. Treatment of acute primidone poisoning with bemegride and amiphenazole. British Medical Journal. 1957 Aug 24;2(5042):451-2. doi:10.1136/bmj.2.5042.451 PMID 13446511
- ^ Rowell NR. Treatment of glutethimide poisoning with bemegride and amiphenazole. Lancet. 1957 Feb 23;272(6965):407-9. PMID 13407028
- ^ Little GM. Use of amiphenazole in respiratory failure. British Medical Journal. 1962 Jan 27;1(5273):223-6. PMID 14465883
- ^ McKeogh J, Shaw FH. Further experience with amiphenazole and morphine in intractable pain. British Medical Journal. 1956 Jan 21;1(4959):142-4. PMID 13276651
- ^ Gershon S, Bruce DW, Orchard N, Shaw FH. Amiphenazole and morphine in production of analgesia. British Medical Journal. 1958 Aug 9;2(5092):366-8. PMID 13560868
- ^ Gairola RL, Gupta PK, Pandley K. Antagonists of morphine-induced respiratory depression. A study in postoperative patients. Anaesthesia. 1980 Jan;35(1):17-21. PMID 6994518
- ^ O'Neill WM. The cognitive and psychomotor effects of opioid drugs in cancer pain management. Cancer Surveys. 1994;21:67-84. PMID 8565000
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