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Amoxapine

 
 

A tricyclic antidepressant, similar to amitriptyline, used in the treatment of psychogenic dermatoses in dogs and cats.

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Wikipedia: Amoxapine
 
Amoxapine
Systematic (IUPAC) name
2-Chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine
Identifiers
CAS number 14028-44-5
ATC code N06AA17
PubChem 2170
DrugBank APRD00142
ChemSpider 2085
Chemical data
Formula C17H16ClN3O 
Mol. mass 313.781
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic (cytochrome P450 system)
Half life 8-10 hours (30 hours for major metabolites)
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(US)

Legal status

-only(US)

Routes Oral

Amoxapine (sold as Asendin, Asendis, Defanyl, Demolox, Moxadil) is a tetracyclic antidepressant (TeCA) of the piperazine and dibenzoxazepine chemical classes.

Contents

Uses

It is used in the treatment of depression, anxiety disorders, panic disorder, and bipolar disorder.

It also has action similar to an atypical antipsychotic.[1]

Pharmacology

Amoxapine is a strong reuptake inhibitor of norepinephrine and weak reuptake inhibitor of serotonin.

Side effects

One of its major metabolites, 7-hydroxyamoxapine, has a dopamine receptor blocking effect, making this drug a common cause of neuroleptic malignant syndrome. Amoxapine is also associated with acute extra pyramidal symptoms and tardive dyskinesia.

Adverse Effects of Amoxapine:

See also

References

  1. ^ Apiquian R, Fresan A, Ulloa RE, et al. (December 2005). "Amoxapine as an atypical antipsychotic: a comparative study vs risperidone". Neuropsychopharmacology 30 (12): 2236–44. doi:10.1038/sj.npp.1300796. PMID 15956984. http://dx.doi.org/10.1038/sj.npp.1300796. 
  • Mosby Year-Book, Inc. (1995). Physician's GenRx: The Complete Drug Reference (5th Ed.). Riverside, CT: Denniston Publishing Co.
  • Palfai, T. & Jankiewicz, H. (1997). Drugs and Human Behavior (2nd Ed.). Madison, WI: Brown & Benchmark.
  • Hedges, D. & Burchfield, C. (2006). Mind, Brain, and Drug: An Introduction to Psychopharmacology. Boston, MA: Pearson.



 
 
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Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Amoxapine" Read more