AMPA

AMPA
IUPAC name 2-amino-3-(5-methyl-3-oxo-1,2- oxazol-4-yl)propanoic acid
Identifiers
CAS number	77521-29-0 N
PubChem	1221
ChemSpider	1184 Y
DrugBank	DB02057
KEGG	C11033 Y
MeSH	AMPA
ChEMBL	CHEMBL276815 N
Jmol-3D images	Image 1
SMILES O=C1/C(=C(\ON1)C)CC(N)C(=O)O
InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12) Y Key: UUDAMDVQRQNNHZ-UHFFFAOYSA-N Y InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12) Key: UUDAMDVQRQNNHZ-UHFFFAOYAT
Properties
Molecular formula	C7H10N2O4
Molar mass	186.17 g mol−1
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

AMPA (2-amino-3-(5-methyl-3-oxo-1,2- oxazol-4-yl)propanoic acid) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.^[1]

There are two types of Ionotropic glutamate receptors that are ligand gated ion channels whose agonists include AMPA, Kainate and NMDA. In the synapse, these two classes of receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions.^[2] AMPA generates fast excitatory postsynaptic potentials (EPSP).^[1] AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na+ and K+ and therefore have an equilibrium potential near 0 mV.

References