Amphibolic
McGraw-Hill Science & Technology Dictionary:
Top
amphibolic
(¦am·fə¦bäl·ik)
(medicine) Uncertain; wavering; refers to the stage of a disease when prognosis is uncertain.
(zoology) Possessing the ability to turn either backward or forward, as the outer toe of certain birds.
Wikipedia on Answers.com:
Top
Amphibolic
 |
This article does not cite any references or sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (December 2009) |
 |
This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (December 2009) |
The term amphibolic is used to describe a biochemical pathway that involves both catabolism and anabolism.[1]This term was proposed by B.Davis in 1961 to emphasise the dual methabolic role of such pathway.[2] The citric acid cycle (The Krebs Cycle) is a good example of amphibolic pathway. The first reaction of the cycle, in which oxaloacetate (a four carbon compound) condenses with acetate (a two carbon compound) to form citrate (a six carbon compound) is typically anabolic. The next few reactions, which are intramolecular rearrangements, produce isocitrate. The following two reactions are typically catabolic. COO is lost in each step and succinate (a four carbon compound) is produced. There is an interesting and critical difference in the coenzymes used in catabolic and anabolic pathways; in catabolism NAD+ serves as an oxidizing agent when it is reduced to NADH. Whereas in anabolism the coenzyme NADPH serves as the reducing agent and is converted to its oxidized form NADP+.
References
- ^ "amphibolic pathway". GenScript. http://www.genscript.com/product_003/molecular_biology_glossary/id/117/category/glossary/amphibolic_pathway.html. Retrieved 2012-03-03.
- ^ Shen, Laura; Fall, Lana; Walton, Gordon; Atkinson, Daniel (1968). "Interaction between energy charge and metabolite modulation in the regulation of enzymes of amphibolic sequences. Phosphofructokinase and pyruvate dehydrogenase". Biochemistry, 7(11), pp.4041-4045. http://pubs.acs.org/doi/abs/10.1021/bi00851a035. Retrieved 3 March 2012.
 |
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Post a question - any question - to the WikiAnswers community:
Copyrights:
McGraw-Hill Science & Technology Dictionary
McGraw-Hill Dictionary of Scientific and Technical Terms. Copyright © 2003, 1994, 1989, 1984, 1978, 1976, 1974 by McGraw-Hill Companies, Inc. All rights reserved.
Read more
