ampholyte-displacement chromatography

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Oxford Dictionary of Biochemistry:

ampholyte-displacement chromatography

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a technique for the fractionation of protein mixtures by displacement chromatography on an ion exchanger using a mobile phase containing a mixture of amphoteric substances of closely spaced isoelectric points (i.e. carrier ampholytes). Separation of the components is thought to involve specific interaction between the proteins and the carrier ampholytes as well as competition between them for sites on the ion exchanger.

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