A synthetic phosphodiesterase inhibitor compound, used to provide inotropic support to the failing myocardium.
Amrinone
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Amrinone
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| Systematic (IUPAC) name | |
| 5-amino-3,4'-bipyridin-6(1H)-one | |
| Identifiers | |
| CAS number | 60719-84-8 |
| ATC code | C01CE01 |
| PubChem | 3698 |
| ChemSpider | 3570 |
| Chemical data | |
| Formula | C10H9N3O |
| Mol. mass | 187.198 g/mol |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | n/a |
| Protein binding | 10 to 49% |
| Metabolism | Hepatic |
| Half life | 5 to 8 hours |
| Excretion | Renal (63%) and fecal (18%) |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status | |
| Routes | Intravenous |
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Amrinone (INN) or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone[1]), trade name Inocor, is a type 3 pyridine phosphodiesterase inhibitor.[2]
Contents |
Uses
It is used in the treatment of congestive heart failure.
It has been studied for use before coronary artery bypass surgery.[3]
Actions
Increases cardiac contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme.
Indications
Short-term management of severe CHF (not used long term because of increased mortality, probably due to heart failure)
Contraindications
Patients with history of hypersensitivity to the drug
Precautions
May increase myocardial ischemia. Blood pressure, pulse, and EKG should be constantly monitored. Amrinone should only be diluted with normal saline or 1/2 normal saline; no dextrose solutions should be used. Furosemide should not be administered into an IV line delivering Amrinone.
Side effects
Thrombocytopenia, hepatotoxicity, arrhythmia, nausea, & vomiting
Routes
IV bolus and infusion as described earlier
Pediatric dosage
Safety in children has not been established
References
- ^ "Amrinone Becomes Inamrinone". USP Quality Review (United States Pharmacopeia) 73. March 2000. http://www.usp.org/hqi/practitionerPrograms/newsletters/qualityReview/qr732000-03-01.html.
- ^ Hamada Y, Kawachi K, Yamamoto T, et al. (August 1999). "Effects of single administration of a phosphodiesterase III inhibitor during cardiopulmonary bypass: comparison of milrinone and amrinone". Japanese circulation journal 63 (8): 605–9. PMID 10478810. http://joi.jlc.jst.go.jp/JST.JSTAGE/jcj/63.605?from=PubMed.
- ^ Kikura M, Sato S (January 2002). "The efficacy of preemptive Milrinone or Amrinone therapy in patients undergoing coronary artery bypass grafting". Anesth. Analg. 94 (1): 22–30, table of contents. PMID 11772795. http://www.anesthesia-analgesia.org/cgi/pmidlookup?view=long&pmid=11772795.
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 | Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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