Teratogenic piperidine alkaloid in Nicotiana spp. Called also neonicotine.
Anabasine
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| Anabasine | |
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| Identifiers | |
| CAS number | |
| SMILES |
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| Properties | |
| Molecular formula | C10H14N2 |
| Molar mass | 162.23 g/mol |
| Density | 1.01 g/ml |
| Melting point |
9 °C, 282 K, 48 °F |
| Boiling point |
270 °C, 543 K, 518 °F |
| Hazards | |
| MSDS | External MSDS |
| Flash point | 93 °C |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Anabasine is a pyridine alkaloid found in the Tree Tobacco (Nicotiana glauca) plant, a close relative of the common tobacco plant (Nicotiana tabacum). Chemically, it is similar to nicotine. Its principal (historical) industrial use is as an insecticide.
Anabasine is present in trace amounts in tobacco smoke, and can be used as an indicator of a person's exposure to tobacco smoke.[1]
Pharmacology
Anabasine is a nicotinic acetylcholine receptor agonist. In high doses, it produces a depolarizing block of nerve transmission, which can cause symptoms similar to those of nicotine poisoning and, ultimately, death by asystole.[2] In larger amounts it is thought to be teratogenic in swine.[3]
The intravenous LD50 of anabasine ranges from 11 mg/kg to 16 mg/kg in mice, depending on the enantiomer.[4]
See also
References
- ^ P. Jacob, 3rd, L. Yu, A. T. Shulgin and N. L. Benowitz (1999). "Minor tobacco alkaloids as biomarkers for tobacco use: comparison of users of cigarettes, smokeless tobacco, cigars, and pipes". Am J Public Health 89 (5): 731–736. doi:. PMID 10224986. http://www.ajph.org/cgi/content/abstract/89/5/731.
- ^ Mizrachi, N.; Levy, S.; Goren, Z. (2000). "Fatal poisoning from nicotiana glauca leaves: identification of anabasine by gas-chromatography/mass spectrometry". Journal of Forensic Sciences 45 (3): 736–741. PMID 10855991.
- ^ "Notes on poisoning: Nicotiana tabacum". Canadian Biodiversity Information Facility. Government of Canada. 2008-03-18. http://www.cbif.gc.ca/pls/pp/ppack.info?p_psn=186&p_type=all&p_sci=sci&p_x=px. Retrieved 2008-05-01.
- ^ Stephen, Lee; Wildeboer, Kristin; Panter, Kip; Kem, William; Gardner, Dale; Molyneux, Russell; Chang, Cheng-Wei; Soti, Ferenc; Pfister, James (2006-02-20). "Neurotoxicology and Teratology". USDA. http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=182063&pf=1. Retrieved 2008-05-01.
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 | Nicotiana |
| Nicotine alkaloids (organic chemistry) |
| Poisonous plants |
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 | Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more |
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