abbr. for anchorage defective-1; a protein (8546 amino acids) of
Caenorhabditis elegans that is involved in the positioning of nuclei and mitochondria within cells. It contains two actin-binding domains, six repeats (each of ≈903 residues) that form coiled coils, and a C-terminal nuclear envelope transmembrane domain. It is homologous with MSP-300 of
Drosophila and the mammalian Syne proteins. Mutations in
anc-1 disrupt the positioning and shape of mitochondria.