Angiocentric lymphoma

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Extranodal NK-T-cell lymphoma
Classification and external resources
ICD-O:	M 9719/3
MeSH	D054391

Angiocentric lymphoma (also known as "Extranodal natural killer cell lymphoma,"^[1] "Nasal-type NK lymphoma,"^[1] "NK/T-cell lymphoma,"^[1] and "Polymorphic/malignant midline reticulosis"^[1]) is a cutaneous condition which in Korea, is reported to be the most common form of cutaneous lymphoma after mycosis fungoides.^[2]^:739

Extranodal NK-T-cell lymphoma is a type of lymphoma.^[3]^[4]^[5]

It is called "extranodal" to emphasize that the location is not in the lymph node. It is sometimes further qualified as "nasal type".

It can be associated with Epstein Barr virus.^[6]^[7]

References

^ ^a ^b ^c ^d Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
^ Lee J, Suh C, Park YH, et al. (February 2006). "Extranodal natural killer T-cell lymphoma, nasal-type: a prognostic model from a retrospective multicenter study". J. Clin. Oncol. 24 (4): 612–8. doi:10.1200/JCO.2005.04.1384. PMID 16380410. http://www.jco.org/cgi/pmidlookup?view=long&pmid=16380410.
^ Lee J, Park YH, Kim WS, et al. (July 2005). "Extranodal nasal type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy". Eur. J. Cancer 41 (10): 1402–8. doi:10.1016/j.ejca.2005.03.010. PMID 15963893. http://linkinghub.elsevier.com/retrieve/pii/S0959-8049(05)00218-2.
^ Lee J, Au WY, Park MJ, et al. (December 2008). "Autologous hematopoietic stem cell transplantation in extranodal natural killer/T cell lymphoma: a multinational, multicenter, matched controlled study". Biol. Blood Marrow Transplant. 14 (12): 1356–64. doi:10.1016/j.bbmt.2008.09.014. PMID 19041057. http://linkinghub.elsevier.com/retrieve/pii/S1083-8791(08)00405-9.
^ Stadlmann S, Fend F, Moser P, Obrist P, Greil R, Dirnhofer S (November 2001). "Epstein-Barr virus-associated extranodal NK/T-cell lymphoma, nasal type of the hypopharynx, in a renal allograft recipient: case report and review of literature". Hum. Pathol. 32 (11): 1264–8. doi:10.1053/hupa.2001.28962. PMID 11727268. http://linkinghub.elsevier.com/retrieve/pii/S0046817701559572.
^ Ferenczi K, Summers P, Aubert P, et al. (December 2008). "A case of CD30+ nasal natural killer/T-cell lymphoma". Am J Dermatopathol 30 (6): 567–71. doi:10.1097/DAD.0b013e318184bc3f. PMID 19033930. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00000372-200812000-00006.

Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)

B cell
(lymphoma,
leukemia)
(most CD19, CD20)

By development/
marker

By infection

KSHV (Primary effusion) · EBV (Lymphomatoid granulomatosis, Post-transplant lymphoproliferative disorder) · HIV (AIDS-related lymphoma) · Helicobacter pylori (MALT lymphoma)

Cutaneous

Diffuse large B-cell lymphoma · Intravascular large B-cell lymphoma · Primary cutaneous marginal zone lymphoma · Primary cutaneous immunocytoma · Plasmacytoma · Plasmacytosis · Primary cutaneous follicular lymphoma

T/NK

T cell
(lymphoma,
leukemia)
(most CD3, CD4, CD8)

By development/
marker

TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)

prolymphocyte (Prolymphocytic)

CD30+ (Anaplastic large-cell lymphoma, Lymphomatoid papulosis type A)

Cutaneous

MF+variants	indolent: Mycosis fungoides · Pagetoid reticulosis · Granulomatous slack skin aggressive: Sézary's disease · Adult T-cell leukemia/lymphoma

Non-MF	CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma · Pleomorphic T-cell lymphoma · Lymphomatoid papulosis type B CD30+: CD30+ cutaneous T-cell lymphoma · Secondary cutaneous CD30+ large cell lymphoma · Lymphomatoid papulosis type A

Other peripheral

Hepatosplenic · Angioimmunoblastic · Enteropathy-associated T-cell lymphoma · Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma) · Subcutaneous T-cell lymphoma

By infection

HTLV-1 (Adult T-cell leukemia/lymphoma)

NK cell/
(most CD56)

Aggressive NK-cell leukemia · Blastic NK cell lymphoma

T or NK

EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma) · Large granular lymphocytic leukemia

Lymphoid+myeloid

Acute biphenotypic leukaemia

Lymphocytosis

Lymphoproliferative disorders (X-linked lymphoproliferative disease, Autoimmune lymphoproliferative syndrome) · Leukemoid reaction · Diffuse infiltrative lymphocytosis syndrome

Cutaneous lymphoid hyperplasia

Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns · Cutaneous lymphoid hyperplasia with nodular pattern · Jessner lymphocytic infiltrate of the skin

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug(L3/4)

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