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Anileridine

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Saunders Veterinary Dictionary:

anileridine

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An opioid used as an analgesic or sedative.

Wikipedia on Answers.com:

Anileridine

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Anileridine
Systematic (IUPAC) name
Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
Clinical data
AHFS/Drugs.com monograph
Pregnancy cat.  ?
Legal status ℞-only (CA) Schedule II (US)
Routes Tablets, injection
Pharmacokinetic data
Protein binding > 95%
Metabolism Hepatic
Identifiers
CAS number 144-14-9 YesY
ATC code N01AH05
PubChem CID 8944
DrugBank DB00913
ChemSpider 8600 YesY
UNII 71Q1A3O279 YesY
KEGG D02941 YesY
ChEBI CHEBI:61203 YesY
ChEMBL CHEMBL1201347 N
Chemical data
Formula C22H28N2O2 
Mol. mass 352.47 g/mol
SMILES eMolecules & PubChem
Physical data
Melt. point 83 °C (181 °F)
 N (what is this?)  (verify)

Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s[1]. It differs from meperidine (Demerol) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.

Anileridine is no longer manufactured in the US or Canada.[2]

Administration

As tablets or injection.[3]

Pharmacokinetics

Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.[4] It is mostly metabolized by the liver.

References

  1. ^ US Patent 2897204
  2. ^ "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. http://www.pharmacists.ca/content/hcp/tools/drugnews/discontinued.htm. Retrieved 28 July 2008. 
  3. ^ "Pharmaceutical Information - LERITINE". RxMed. http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20%28General%20Monographs-%20L%29/LERITINE.html. Retrieved 16 June 2010. 
  4. ^ "Anileridine Consumer Information". MedicineNet. http://www.medicinenet.com/anileridine-oral_tablet/article.htm. Retrieved 28 July 2008. 
Opioids
See also: Opioids template
Opium & alkaloids thereof
Semi-synthetic opium
derivatives
Synthetic opioids
Pyrazolones
Cannabinoids
Anilides
Non-steroidal
anti-inflammatories
See also: NSAIDs template
Propionic acid class
Oxicam class
Acetic acid class
Anthranilic acid
(fenamate) class
Atypical, adjuvant and potentiators,
Metabolic agents and miscellaneous
Inhalation
Others
Injection
Alfentanil • Anileridine • Fentanyl • Phenoperidine • Remifentanil • Sufentanil 
Others
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Cite
Saunders Veterinary Dictionary Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved. Read more
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Wikipedia on Answers.com This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article Anileridine. Read more

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