anion channel protein
Oxford Dictionary of Biochemistry:
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anion channel protein
or band 3 protein or anion exchanger or Cl−/HCO3− exchanger
either of two integral plasma membrane glycoproteins, both 911 residues long and showing ≈70% sequence homology. Their N-terminal 403 residues are cytoplasmic, the rest form 12 — 14 putative transmembrane segments. AE1 (locus at 17q21 — q22), the erythroid form, is predominant in erythrocyte membranes, where it mediates exchange of Cl− for HCO3− and is the major site for anchoring of the submembranous cytoskeleton. Mutations at this locus are associated with hereditary spherocytosis, elliptocytosis, ovalocytosis, or acanthocytosis, or with distal renal tubular acidosis. An isoform of AE1 that lacks the N-terminal 66 residues occurs in the basolateral membrane of cells of renal collecting ducts. AE2 (locus on chromosome 7) is the non-erythroid form. See band protein.
either of two integral plasma membrane glycoproteins, both 911 residues long and showing ≈70% sequence homology. Their N-terminal 403 residues are cytoplasmic, the rest form 12 — 14 putative transmembrane segments. AE1 (locus at 17q21 — q22), the erythroid form, is predominant in erythrocyte membranes, where it mediates exchange of Cl− for HCO3− and is the major site for anchoring of the submembranous cytoskeleton. Mutations at this locus are associated with hereditary spherocytosis, elliptocytosis, ovalocytosis, or acanthocytosis, or with distal renal tubular acidosis. An isoform of AE1 that lacks the N-terminal 66 residues occurs in the basolateral membrane of cells of renal collecting ducts. AE2 (locus on chromosome 7) is the non-erythroid form. See band protein.
| anion, animal protein factor, anhydrous | |
| anion exchanger, anion gap, anionic detergent |
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Oxford Dictionary of Biochemistry
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