antanamide

a highly lipophilic homodetic cyclic decapeptide, cyclo(-Pro-Phe-Phe-Val-Pro-Pro-Ala-Phe-Phe-Pro-). It occurs in the death-cap fungus, Amanita phalloides, together with the amatoxins and phallotoxins. When administered to experimental animals (at 1 mg per kg of body weight), either before or at most a few minutes after a lethal dose of phallotoxin, it acts as an antidote to the toxin, apparently by competing for binding sites. In vitro it readily forms complexes with sodium and calcium ions, and can act as a sodium ionophore.

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