Anti-cardiolipin antibodies
Wikipedia on Answers.com:
Top
Anti-cardiolipin antibodies
Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases including syphilis[1], antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome[2], idiopathic spontaneous abortion,[3] and systemic lupus erythematosus(SLE).[4] They are a form of anti-mitochondrial antibody. In SLE, The anti-DNA antibodies and anti-cardiolipin act independently.[5] In rheumatoid arthritis[6] with systemic sclerosis (scleroderma)[7] these antibodies may tie two conditions together.
Anti-cardiolipin antibodies can be classified in two ways.
- As IgM, IgG or IgA
- As β2-glycoprotein dependent or independent
- In autoimmune disease ACA are beta-2 glycoprotein dependent
- syphilis ACA[1] are beta-2 glycoprotein independent and can be assayed using the Venereal Disease Research Laboratory test
Apolipoprotein H involvement
β2-glycoprotein I has been identified as Apolipoprotein H and is required for the recognition of ACA in autoimmune disease.[8] Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with increased thrombosis.
References
- ^ a b Tringali GR, Julian AJ, Halbert WM (1969). "Effect of 2-mercaptoethanol treatment on anticardiolipin reactivity in sera from syphilitics and false positive reactors". The British journal of venereal diseases 45 (3): 202–4. PMC 1048465. PMID 5346419. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1048465.
- ^ Hull RG, Harris EN, Gharavi AE et al (1984). "Anticardiolipin antibodies: occurrence in Behçet's syndrome". Ann. Rheum. Dis. 43 (5): 746–748. doi:10.1136/ard.43.5.746. PMC 1001520. PMID 6497467. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1001520.
- ^ Petri M, Golbus M, Anderson R, Whiting-O'Keefe Q, Corash L, Hellmann D (1987). "Antinuclear antibody, lupus anticoagulant, and anticardiolipin antibody in women with idiopathic habitual abortion. A controlled, prospective study of forty-four women". Arthritis Rheum. 30 (6): 601–606. doi:10.1002/art.1780300601. PMID 3111489.
- ^ Harris EN, Gharavi AE, Boey ML et al (1983). "Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus". Lancet 2 (8361): 1211–1214. doi:10.1016/S0140-6736(83)91267-9. PMID 6139567.
- ^ Harris EN, Gharavi AE, Loizou S et al (1985). "Crossreactivity of antiphospholipid antibodies". Journal of clinical & laboratory immunology 16 (1): 1–6. PMID 3981615.
- ^ Keane A, Woods R, Dowding V, Roden D, Barry C (1987). "Anticardiolipin antibodies in rheumatoid arthritis". Br. J. Rheumatol. 26 (5): 346–350. doi:10.1093/rheumatology/26.5.346. PMID 3664159.
- ^ Malia RG, Greaves M, Rowlands LM et al (1988). "Anticardiolipin antibodies in systemic sclerosis: immunological and clinical associations". Clin. Exp. Immunol. 73 (3): 456–60. PMC 1541778. PMID 2974767. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1541778.
- ^ McNeil HP, Simpson RJ, Chesterman CN, Krilis SA (1990). "Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)". Proc. Natl. Acad. Sci. U.S.A. 87 (11): 4120–4124. doi:10.1073/pnas.87.11.4120. PMC 54059. PMID 2349221. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=54059.
|
||||||||||||||||||||||||||||
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Related Videos:
Top
Anti-cardiolipin antibodies
Post a question - any question - to the WikiAnswers community:
Copyrights:
Wikipedia on Answers.com
This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article Anti-cardiolipin antibodies.
Read more