Anti-Itch Drugs: Precautions
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This medicine should not be used for more than four months at a time because its effects can wear off. See a physician regularly while taking the medicine to determine whether it is still needed.
Hydroxyzine may add to the effects of alcohol and other drugs that slow down the central nervous system, such as other antihistamines, cold medicine, allergy medicine, sleep aids, medicine for seizures, tranquilizers, some pain relievers, and muscle relaxants. Anyone taking hydroxyzine should not drink alcohol and should check with his or her physician before taking any of the above.
Some people feel drowsy or less alert when using this medicine. Anyone who takes it should not drive, use machines, or do anything else that might be dangerous until they have found out how the drugs affect them.
Anyone who has had unusual reactions to hydroxyzine in the past should let his or her physician know before taking the medicine again. The physician should also be told about any allergies to foods, dyes, preservatives, or other substances.
A woman who is pregnant or who may become pregnant should check with her physician before taking this medicine. In studies of laboratory animals, hydroxyzine has caused birth defects when taken during pregnancy. Although the drug's effects on pregnant women have not been fully studied, physicians advise against taking it in early pregnancy.
BREASTFEEDING. Women who are breastfeeding should also check with their physicians before using hydroxyzine. The medicine may pass into breast milk and may cause problems in nursing babies whose mothers take it.
— Nancy Ross-Flanigan




