Antianxiety Drugs: Interactions
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The metabolism of alprazolam may be increased by: cimetidine, oral contraceptives, disulfiram, fluoxetine, isoniazid, ketoconazole, metoprolol, propoxyphene, propranolol and valproic acid. The absorption of all benzodiazepines is inhibited by concomitant use of antacids. Benzodiazepines may increase blood devels of digoxin, and reduce the efficacy of levodopa. Other drug interactions have been reported.
Buspirone levels will be increased by concomitant use of erythromycin, itraconazole, and nefazadone. Doses should be adjusted based on clinical response. Use of buspirone at the same time as mono-amine oxidase inhibitors (MAOIs, phenelzine, tranycypromine) may cause severe blood pressure elevations. Use of buspirone with MAOIs should be avoided.
[Article by: Samuel Uretsky, PharmD]
— Samuel Uretsky, PharmD
