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The most common side effects of benzodiazepines are secondary to their CNS effects and include sedation and sleepiness; depression; lethargy; apathy; fatigue; hypoactivity; lightheadedness; memory impairment; disorientation; anterograde amnesia; restlessness; confusion; crying or sobbing; delirium; headache; slurred speech; aphonia; dysarthria; stupor; seizures; coma; syncope; rigidity; tremor; dystonia; vertigo; dizziness; euphoria; nervousness; irritability; difficulty in concentration; agitation; inability to perform complex mental functions; akathisia; hemiparesis; hypotonia; unsteadiness; ataxia; incoordination; weakness; vivid dreams; psychomotor retardation; "glassy-eyed" appearance; extrapyramidal symptoms; paradoxical reactions. Other reactions include changes in heart rate and blood pressure, changes in bowel function, severe skin rash and changes in genitourinary function. Other adverse effects have been reported.
Buspirone has a low incidence of side effects. Dizziness and drowsiness are the most commonly reported adverse effects. Other CNS effects include dream disturbances; depersonalization, dysphoria, noise intolerance, euphoria, akathisia, fearfulness, loss of interest, disassociative reaction, hallucinations, suicidal ideation, seizures; feelings of claustrophobia, cold intolerance, stupor and slurred speech, psychosis. Rarely, heart problems, including congestive heart failure and myocardial infarction, have been reported. Other adverse effects have been reported.
— Samuel Uretsky, PharmD
