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antisense

 
Dictionary: an·ti·sense   (ăn'tē-sĕns', ăn'tī-) pronunciation
Home > Library > Literature & Language > Dictionary
adj.
Of or relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it.


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Columbia Encyclopedia: antisense
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Home > Library > Miscellaneous > Columbia Encyclopedia
antisense, DNA or RNA manipulated in a laboratory so that its components (nucleotides) form a complementary copy of normal, or "sense," messenger RNA (mRNA; see nucleic acid). Antisense techniques are used to deactivate disease-causing or undesirable genes so that they cannot produce harmful or unwanted proteins. (Conventional drugs bind directly with disease-causing protein molecules, but their imperfect specificity may lead them to bind with other protein molecules, resulting in unwanted side effects. Antisense molecules are extremely specific.) In some applications of this technique, the antisense nucleic acid segment is inserted into an inactivated or nonvirulent virus, then introduced into the cell. The antisense segment pairs with the mRNA, preventing the synthesis of protein by the mRNA. Antisense has applications in agricultural biotechnology, where it has been used to deactivate the gene that causes softening in tomatoes, and in medicine, especially in cancer and antiviral therapy. See also gene therapy.

Medical Dictionary: an·ti·sense
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Home > Library > Health > Medical Dictionary
(ăn'tē-sĕns', ăn'tī-)
adj.

Of, relating to, or being nucleotide sequences that mimic DNA sequences but cannot serve as a template for mRNA, thus serving to disrupt genetic replication.

Translations: Antisense
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Dansk (Danish)
adj. - anti-sense

Nederlands (Dutch)
het functioneren van genen tegenhoudend (biologie)

Français (French)
adj. - contre-sens

Deutsch (German)
adj. - in Komplementärsequenz mit Genstück, die Genfunktion hemmend

Ελληνική (Greek)
adj. - (βιολ.) (για γονίδιο) ανάστροφος

Italiano (Italian)
controsenso

Português (Portuguese)
adj. - sem sentido

Русский (Russian)
(о цепи фНК) комплементарная, не несущая информацию о структуре

Español (Spanish)
adj. - antígeno

Svenska (Swedish)
adj. - som hämmar genfunktionen

中文（简体）(Chinese (Simplified))
反意识的

中文（繁體）(Chinese (Traditional))
adj. - 反意識的

한국어 (Korean)
adj. - 비감각적인

日本語 (Japanese)
n. - 反感覚

العربيه (Arabic)
‏(صفه) غير منطقي, رفض المنطق‏

עברית (Hebrew)
adj. - ‮של גן המוחדר לAND ומשמש בהנדסה גנטית לוויסות ביטוי גנטי לתכונה‬

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Learn More
small nucleolar ribonucleic acid (cell and molecular biology)
Antisense Nucleotides
AVI BioPharma, Inc. (Public Company)

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Copyrights:

Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved.  Read more
Columbia Encyclopedia. The Columbia Electronic Encyclopedia, Sixth Edition Copyright © 2003, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/.  Read more
Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company.  Read more
Translations. Copyright © 2007, WizCom Technologies Ltd. All rights reserved.  Read more