Antiseptics: Precautions
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Precautions vary with individual product and use. Consult individualized references.
Hypersensitivity reactions should be considered with organic compounds such as chlorhexidine, benzalkonium and hexachlorophine.
Skin dryness and irritation should be considered with all products, but particularly with those containing alcohol.
Systemic toxicity may result from ingestion of iodine containing compounds or mercury compounds.
Chlorhexidine should not be instilled into the ear. There is one anecdotal report of deafness following use of chlorhexidine in a patient with a perforated eardrum. Safety in pregnancy and breastfeeding have not been reported, however there is one anecdotal report of an infant developing slowed heartbeat apparently related to maternal use of chlorhexidine.
Iodine compounds should be used sparingly during pregnancy and lactation due to risk of infant absorption of iodine with alterations in thyroid function.
— Samuel Uretsky, PharmD
