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| Apolipoprotein A-V | ||||||||||||||
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| Identifiers | ||||||||||||||
| Symbols | APOA5; APOA-V; APOAV; MGC126836; MGC126838; RAP3 | |||||||||||||
| External IDs | OMIM: 606368 MGI: 1913363 HomoloGene: 14197 | |||||||||||||
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| Orthologs | ||||||||||||||
| Species | Human | Mouse | ||||||||||||
| Entrez | 116519 | 66113 | ||||||||||||
| Ensembl | ENSG00000110243 | ENSMUSG00000032079 | ||||||||||||
| UniProt | Q6Q788 | Q8C7G5 | ||||||||||||
| RefSeq | NM_052968 (mRNA) | NM_080434 (mRNA) | ||||||||||||
| NP_443200 (protein) | NP_536682 (protein) | |||||||||||||
| Location | Chr 11: 116.17 - 116.17 Mb |
Chr 9: 46.02 - 46.02 Mb |
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| PubMed search | [1] | [2] | ||||||||||||
Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene.[1][2][3]
The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of several lipoprotein fractions including VLDL, HDL, chylomicrons. It is believed that apoA-V affects lipoprotein metabolism by interacting with LDL-R gene family receptors.[4]
This gene uses alternate polyadenylation sites and is located proximal to the apolipoprotein gene cluster on chromosome 11q23.[3]
See also
References
- ^ Pennacchio LA, Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC, Krauss RM, Rubin EM (Oct 2001). "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing". Science 294 (5540): 169-73. doi:. PMID 11588264.
- ^ van der Vliet HN, Sammels MG, Leegwater AC, Levels JH, Reitsma PH, Boers W, Chamuleau RA (Nov 2001). "Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration". J Biol Chem 276 (48): 44512-20. doi:. PMID 11577099.
- ^ a b "Entrez Gene: APOA5 apolipoprotein A-V". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116519.
- ^ Nilsson SK, Christensen S, Raarup MK, Ryan RO, Nielsen MS, Olivecrona G (July 2008). "Endocytosis of apolipoprotein AV by members of the low density lipoprotein receptor and the Vps10p domain receptor families". J. Biol. Chem. 283: 25920. doi:. PMID 18603531.
Further reading
- Pennacchio LA, Rubin EM (2004). "Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice.". Arterioscler. Thromb. Vasc. Biol. 23 (4): 529–34. doi:. PMID 12615678.
- Jakel H, Nowak M, Helleboid-Chapman A, et al. (2006). "Is apolipoprotein A5 a novel regulator of triglyceride-rich lipoproteins?". Ann. Med. 38 (1): 2–10. doi:. PMID 16448983.
- Calandra S, Priore Oliva C, Tarugi P, Bertolini S (2007). "APOA5 and triglyceride metabolism, lesson from human APOA5 deficiency.". Curr. Opin. Lipidol. 17 (2): 122–7. doi:. PMID 16531747.
- Wong K, Ryan RO (2007). "Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation.". Curr. Opin. Lipidol. 18 (3): 319–24. doi:. PMID 17495607.
- Nabika T, Nasreen S, Kobayashi S, Masuda J (2003). "The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese.". Atherosclerosis 165 (2): 201–4. doi:. PMID 12417270.
- Pennacchio LA, Olivier M, Hubacek JA, et al. (2003). "Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels.". Hum. Mol. Genet. 11 (24): 3031–8. doi:. PMID 12417524.
- Talmud PJ, Hawe E, Martin S, et al. (2003). "Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.". Hum. Mol. Genet. 11 (24): 3039–46. doi:. PMID 12417525.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Vu-Dac N, Gervois P, Jakel H, et al. (2003). "Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators.". J. Biol. Chem. 278 (20): 17982–5. doi:. PMID 12637506.
- Prieur X, Coste H, Rodriguez JC (2003). "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element.". J. Biol. Chem. 278 (28): 25468–80. doi:. PMID 12709436.
- Weinberg RB, Cook VR, Beckstead JA, et al. (2003). "Structure and interfacial properties of human apolipoprotein A-V.". J. Biol. Chem. 278 (36): 34438–44. doi:. PMID 12810715.
- Horínek A, Vráblík M, Ceska R, et al. (2003). "T-1131-->C polymorphism within the apolipoprotein AV gene in hypertriglyceridemic individuals.". Atherosclerosis 167 (2): 369–70. doi:. PMID 12818421.
- Beckstead JA, Oda MN, Martin DD, et al. (2003). "Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis.". Biochemistry 42 (31): 9416–23. doi:. PMID 12899628.
- Kao JT, Wen HC, Chien KL, et al. (2004). "A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia.". Hum. Mol. Genet. 12 (19): 2533–9. doi:. PMID 12915450.
- Vrablík M, Horínek A, Ceska R, et al. (2003). "Ser19-->Trp polymorphism within the apolipoprotein AV gene in hypertriglyceridaemic people.". J. Med. Genet. 40 (8): e105. doi:. PMID 12920097.
- Lai CQ, Tai ES, Tan CE, et al. (2004). "The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore.". J. Lipid Res. 44 (12): 2365–73. doi:. PMID 12951359.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:. PMID 12975309.
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