Apolipoprotein D is a protein that in humans is encoded by the APOD gene.[1][2][3]
Apolipoprotein D (Apo-D) is a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. It is a glycoprotein of estimated molecular weight 33 KDa. Apo-D is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism.[3]
References
- ^ Drayna DT, McLean JW, Wion KL, Trent JM, Drabkin HA, Lawn RM (Aug 1987). "Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha 2u-globulin superfamily". DNA 6 (3): 199-204. PMID 2439269.
- ^ Drayna D, Fielding C, McLean J, Baer B, Castro G, Chen E, Comstock L, Henzel W, Kohr W, Rhee L, et al. (Jan 1987). "Cloning and expression of human apolipoprotein D cDNA". J Biol Chem 261 (35): 16535-9. PMID 3453108.
- ^ a b "Entrez Gene: APOD apolipoprotein D". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=347.
Further reading
- Rassart E, Bedirian A, Do Carmo S, et al. (2000). "Apolipoprotein D.". Biochim. Biophys. Acta 1482 (1-2): 185–98. PMID 11058760.
- Peitsch MC, Boguski MS (1991). "Is apolipoprotein D a mammalian bilin-binding protein?". New Biol. 2 (2): 197–206. PMID 2083249.
- Balbín M, Freije JM, Fueyo A, et al. (1990). "Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease.". Biochem. J. 271 (3): 803–7. PMID 2244881.
- Drayna D, Scott JD, Lawn R (1988). "Multiple RFLPs at the human apolipoprotein D (APOD) locus.". Nucleic Acids Res. 15 (22): 9617. doi:10.1093/nar/15.22.9617. PMID 2891117.
- Fielding PE, Fielding CJ (1980). "A cholesteryl ester transfer complex in human plasma.". Proc. Natl. Acad. Sci. U.S.A. 77 (6): 3327–30. doi:10.1073/pnas.77.6.3327. PMID 6774335.
- Schindler PA, Settineri CA, Collet X, et al. (1995). "Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion.". Protein Sci. 4 (4): 791–803. PMID 7613477.
- Yang CY, Gu ZW, Blanco-Vaca F, et al. (1994). "Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links.". Biochemistry 33 (41): 12451–5. doi:10.1021/bi00207a011. PMID 7918467.
- Holzfeind P, Merschak P, Dieplinger H, Redl B (1996). "The human lacrimal gland synthesizes apolipoprotein D mRNA in addition to tear prealbumin mRNA, both species encoding members of the lipocalin superfamily.". Exp. Eye Res. 61 (4): 495–500. doi:10.1016/S0014-4835(05)80145-9. PMID 8549691.
- Zeng C, Spielman AI, Vowels BR, et al. (1996). "A human axillary odorant is carried by apolipoprotein D.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6626–30. doi:10.1073/pnas.93.13.6626. PMID 8692868.
- Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209.
- Liu Z, Chang GQ, Leibowitz SF (2001). "Apolipoprotein D interacts with the long-form leptin receptor: a hypothalamic function in the control of energy homeostasis.". Faseb J. 15 (7): 1329–31. PMID 11344130.
- Sánchez D, Ganfornina MD, Martínez S (2002). "Expression pattern of the lipocalin apolipoprotein D during mouse embryogenesis.". Mech. Dev. 110 (1-2): 225–9. doi:10.1016/S0925-4773(01)00578-0. PMID 11744388.
- Mahadik SP, Khan MM, Evans DR, Parikh VV (2002). "Elevated plasma level of apolipoprotein D in schizophrenia and its treatment and outcome.". Schizophrenia Research 58 (1): 55–62. doi:10.1016/S0920-9964(01)00378-4. PMID 12363390.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Desai PP, Hendrie HC, Evans RM, et al. (2003). "Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-Americans.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 116 (1): 98–101. doi:10.1002/ajmg.b.10798. PMID 12497622.
- Kang MK, Kameta A, Shin KH, et al. (2003). "Senescence-associated genes in normal human oral keratinocytes.". Exp. Cell Res. 287 (2): 272–81. doi:10.1016/S0014-4827(03)00061-2. PMID 12837283.
- Thomas EA, Laws SM, Sutcliffe JG, et al. (2003). "Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype.". Biol. Psychiatry 54 (2): 136–41. doi:10.1016/S0006-3223(02)01976-5. PMID 12873803.
External links
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
