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The noun has 2 meanings:
Meaning #1:
coarse South American herb grown for its blue-and-white flowers followed by a bladderlike fruit enclosing a dry berry
Synonyms: shoo fly, Nicandra physaloides
Meaning #2:
intensely poisonous tall coarse annual tropical weed having rank-smelling foliage, large white or violet trumpet-shaped flowers and prickly fruits
Synonyms: jimsonweed, jimson weed, Jamestown weed, common thorn apple, Datura stramonium