Aquaretics
Saunders Veterinary Dictionary:
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aquaretics
Drugs that bind to vasopressin receptors in the renal collecting duct promoting excretion of solute-free water.
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Aquaretics
An aquaretic is a class of drug that is used to promote aquaresis. They are not strictly speaking diuretics, but are sometimes classified as such.
Pharmacokinetics
These increase blood flow to the kidneys without increasing sodium and chloride resorption, thus causing an increase in urine whilst retaining electrolytes. However, the increase in intravascular fluid volume that they cause translates into an increase vascular resistance, and higher blood pressure.[1]
Chemical constituents
Synthetic aquaretics, a new class of drug, are V2 receptor antagonists, such as OPC-31260. Additional examples include conivaptan, demeclocycline, and lithium. These have been used in clinical trials as a treatment for Syndrome of inappropriate antidiuretic hormone (SIADH).[2][3]
References
- ^ Lucinda G. Miller and Wallace J. Murray (1998). Herbal Medicinals: A Clinician's Guide. Haworth Press. pp. 147. ISBN 0-7890-0466-6.
- ^ Toshikazu Saito, San-e Ishikawa, Keishi Abe, Kyuzi Kamoi, Kenichi Yamada, Kurakazu Shimizu, Takao Saruta and Sho Yoshida (April 1997). "Acute Aquaresis by the Nonpeptide Arginine Vasopressin (AVP) Antagonist OPC-31260 Improves Hyponatremia in Patients with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)". The Journal of Clinical Endocrinology & Metabolism (The Endocrine Society) 82 (4): 1054–1057. PMID 9100572.
- ^ D. A. Warrell, Timothy M. Cox, and John D. Firth (2003). Oxford Textbook of Medicine. Oxford University Press. pp. 211–212. ISBN 0-19-856978-5.
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Saunders Veterinary Dictionary
Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.
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