Arginine vasopressin receptor 2
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Arginine vasopressin receptor 2
Arginine vasopressin receptor 2 (officially abbreviated AVPR2) is a protein that acts as receptor for arginine vasopressin.[1] AVPR2 belongs to the subfamily of G-protein-coupled receptors. Its activity is mediated by the Gs type of G proteins, which stimulate adenylate cyclase.
AVPR2 is expressed in the kidney tubule, predominantly in the membrane of cells of the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer, the last two being associated with alternative splicing. AVPR2 is also expressed outside the kidney, and, when stimulated, a variety of clotting factors are released into the bloodstream.
In the kidney, AVPR2's primary property is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of AVPR2 is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results.
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Contents
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Antagonists
Further information: Vasopressin receptor antagonist
Vasopressin receptor antagonists that are selective for the V2 receptor include:
- Tolvaptan (FDA-approved)
- Lixivaptan
- Mozavaptan
- Satavaptan
Their main uses are in hyponatremia, such as that caused by syndrome of inappropriate antidiuretic hormone (SIADH) and cirrhosis.
Interactions
Arginine vasopressin receptor 2 has been shown to interact with C1QTNF1.[2]
References
- ^ van den Ouweland AM, Knoop MT, Knoers VV, Markslag PW, Rocchi M, Warren ST, Ropers HH, Fahrenholz F, Monnens LA, van Oost BA (1992). "Colocalization of the gene for nephrogenic diabetes insipidus (DIR) and the vasopressin type 2 receptor gene (AVPR2) in the Xq28 region". Genomics 13 (4): 1350–2. doi:10.1016/0888-7543(92)90067-3. PMID 1324225.
- ^ Innamorati, Giulio; Whang Michael Insuk, Molteni Raffaella, Le Gouill Christian, Birnbaumer Mariel (Nov. 2002). "GIP, a G-protein-coupled receptor interacting protein". Regul. Pept. (Netherlands) 109 (1–3): 173–9. doi:10.1016/S0167-0115(02)00201-X. ISSN 0167-0115. PMID 12409230.
Further reading
- Birnbaumer M (2001). "The V2 vasopressin receptor mutations and fluid homeostasis". Cardiovasc. Res. 51 (3): 409–15. doi:10.1016/S0008-6363(01)00337-6. PMID 11476731.
- Ishikawa SE (2002). "[Nephrogenic diabetes insipidus associated with mutations of vasopressin V2 receptors and aquaporin-2]". Nippon Rinsho 60 (2): 350–5. PMID 11857925.
- Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). "Molecular pharmacology and modeling of vasopressin receptors". Prog. Brain Res. 139: 179–96. doi:10.1016/S0079-6123(02)39016-2. PMID 12436935.
- Bichet DG (2006). "Nephrogenic diabetes insipidus". Advances in chronic kidney disease 13 (2): 96–104. doi:10.1053/j.ackd.2006.01.006. PMID 16580609.
- Robben JH, Knoers NV, Deen PM (2006). "Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus". Am. J. Physiol. Renal Physiol. 291 (2): F257–70. doi:10.1152/ajprenal.00491.2005. PMID 16825342.
- Pan Y, Metzenberg A, Das S, et al. (1993). "Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus". Nat. Genet. 2 (2): 103–6. doi:10.1038/ng1092-103. PMID 1303257.
- van den Ouweland AM, Dreesen JC, Verdijk M, et al. (1993). "Mutations in the vasopressin type 2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus". Nat. Genet. 2 (2): 99–102. doi:10.1038/ng1092-99. PMID 1303271.
- van den Ouweland AM, Knoop MT, Knoers VV, et al. (1992). "Colocalization of the gene for nephrogenic diabetes insipidus (DIR) and the vasopressin type 2 receptor gene (AVPR2) in the Xq28 region". Genomics 13 (4): 1350–2. doi:10.1016/0888-7543(92)90067-3. PMID 1324225.
- Rosenthal W, Seibold A, Antaramian A, et al. (1992). "Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus". Nature 359 (6392): 233–5. doi:10.1038/359233a0. PMID 1356229.
- Seibold A, Brabet P, Rosenthal W, Birnbaumer M (1992). "Structure and chromosomal localization of the human antidiuretic hormone receptor gene". Am. J. Hum. Genet. 51 (5): 1078–83. PMC 1682836. PMID 1415251. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1682836.
- Birnbaumer M, Seibold A, Gilbert S, et al. (1992). "Molecular cloning of the receptor for human antidiuretic hormone". Nature 357 (6376): 333–5. doi:10.1038/357333a0. PMID 1534149.
- Lolait SJ, O'Carroll AM, McBride OW, et al. (1992). "Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus". Nature 357 (6376): 336–9. doi:10.1038/357336a0. PMID 1534150.
- Knoers N, van der Heyden H, van Oost BA, et al. (1989). "Three-point linkage analysis using multiple DNA polymorphic markers in families with X-linked nephrogenic diabetes insipidus". Genomics 4 (3): 434–7. doi:10.1016/0888-7543(89)90352-2. PMID 2714800.
- Tsukaguchi H, Matsubara H, Taketani S, et al. (1995). "Binding-, intracellular transport-, and biosynthesis-defective mutants of vasopressin type 2 receptor in patients with X-linked nephrogenic diabetes insipidus". J. Clin. Invest. 96 (4): 2043–50. doi:10.1172/JCI118252. PMC 185843. PMID 7560098. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=185843.
- Faà V, Ventruto ML, Loche S, et al. (1995). "Mutations in the vasopressin V2-receptor gene in three families of Italian descent with nephrogenic diabetes insipidus". Hum. Mol. Genet. 3 (9): 1685–6. doi:10.1093/hmg/3.9.1685. PMID 7833930.
- Birnbaumer M, Gilbert S, Rosenthal W (1995). "An extracellular congenital nephrogenic diabetes insipidus mutation of the vasopressin receptor reduces cell surface expression, affinity for ligand, and coupling to the Gs/adenylyl cyclase system". Mol. Endocrinol. 8 (7): 886–94. doi:10.1210/me.8.7.886. PMID 7984150.
- Wenkert D, Merendino JJ, Shenker A, et al. (1995). "Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus". Hum. Mol. Genet. 3 (8): 1429–30. doi:10.1093/hmg/3.8.1429. PMID 7987330.
- Oksche A, Dickson J, Schülein R, et al. (1995). "Two novel mutations in the vasopressin V2 receptor gene in patients with congenital nephrogenic diabetes insipidus". Biochem. Biophys. Res. Commun. 205 (1): 552–7. doi:10.1006/bbrc.1994.2700. PMID 7999078.
- Bichet DG, Birnbaumer M, Lonergan M, et al. (1994). "Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus". Am. J. Hum. Genet. 55 (2): 278–86. PMC 1918376. PMID 8037205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1918376.
- Yuasa H, Ito M, Oiso Y, et al. (1994). "Novel mutations in the V2 vasopressin receptor gene in two pedigrees with congenital nephrogenic diabetes insipidus". J. Clin. Endocrinol. Metab. 79 (2): 361–5. doi:10.1210/jc.79.2.361. PMID 8045948.
External links
- GeneReviews/NCBI/NIH/UW entry on Nephrogenic Diabetes Insipidus
- "Symbol Report: AVPR2". Human Geneome Organization Gene Nomenclature Committee. http://www.genenames.org/data/hgnc_data.php?hgnc_id=897.
- "Vasopressin and Oxytocin Receptors: V2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2964.
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