Arotinolol
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Arotinolol
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| Systematic (IUPAC) name | |
| (RS)-5-(2-{[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl}- 1,3-thiazol-4-yl)thiophene-2-carboxamide | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ℞ Prescription only |
| Routes | Oral |
| Pharmacokinetic data | |
| Bioavailability | 2h |
| Half-life | 10h |
| Identifiers | |
| CAS number | 41287-43-8  |
| ATC code | None |
| PubChem | CID 2239 |
| ChemSpider | 2152  |
| UNII | 394E3P3B99 |
| KEGG | D07465 |
| ChEMBL | CHEMBL93298 |
| Chemical data | |
| Formula | C15H21N3O2S3 |
| Mol. mass | 371.54 g/mol |
| SMILES | eMolecules & PubChem |
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Arotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers. [1]
Uses
It is used in the treatment of high blood pressure.[2]
It has been proposed for use in treatment of essential tremor.[3]
Recommended dosage 10 - 30 mg
References
- ^ Zhao J, Golozoubova V, Cannon B, Nedergaard J (July 2001). "Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes". Can. J. Physiol. Pharmacol. 79 (7): 585–93. doi:10.1139/cjpp-79-7-585. PMID 11478592. http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?issn=0008-4212&volume=79&issue=7&startPage=585.
- ^ Wu H, Zhang Y, Huang J, et al. (September 2001). "Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers" ([dead link] – Scholar search). Hypertens. Res. 24 (5): 605–10. doi:10.1291/hypres.24.605. PMID 11675958. http://joi.jlc.jst.go.jp/JST.JSTAGE/hypres/24.605?from=PubMed.
- ^ Lee KS, Kim JS, Kim JW, Lee WY, Jeon BS, Kim D (August 2003). "A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor". Parkinsonism Relat. Disord. 9 (6): 341–7. doi:10.1016/S1353-8020(03)00029-4. PMID 12853233. http://linkinghub.elsevier.com/retrieve/pii/S1353802003000294.
External links
- (Japanese) Almarl アルマール (PDF) Dainippon Sumitomo Pharma. April 2002.
- (Japanese) Official Dainippon Sumitomo Pharma Website
http://sdic.sookmyung.ac.kr/drug_monograph/view.asp?id=92
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