AS-19
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AS-19 (drug)
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| Systematic (IUPAC) name | |
| (2S)-N,N-dimethyl-5-(1,3,5-trimethylpyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| ATC code | ? |
| PubChem | CID 23642275 |
| ChemSpider | 24605931  |
| Chemical data | |
| Formula | C18H25N3 |
| Mol. mass | 283.411 g/mol |
| SMILES | eMolecules & PubChem |
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AS-19 is a substance which acts as a potent agonist at the 5HT7 receptor, with an IC50 of 0.83nM. It reverses the amnesia induced by drugs such as scopolamine and dizocilpine and improves long term memory acquisition, but inhibits short term memory formation.[1][2]
See also
References
- ^ Meneses, A; Perez-Garcia, G; Liy-Salmeron, G; Flores-Galvez, D; Castillo, C; Castillo, E (2008). "The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation". Behavioural Brain Research 195 (1): 112–9. doi:10.1016/j.bbr.2007.11.023. PMID 18191236.
- ^ Perez-García, G; Meneses, A (2008). "Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia". Behavioural Brain Research 195 (1): 139–46. doi:10.1016/j.bbr.2008.07.033. PMID 18723050.
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