ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Identifiers
Symbols	ASAH2; BCDase; HNAC1; MGC129777; NCDase
External IDs	OMIM: 611202 MGI: 1859310 HomoloGene: 10310 GeneCards: ASAH2 Gene
EC number	3.5.1.23
Gene Ontology Molecular function • hydrolase activity • ceramidase activity Cellular component • mitochondrion • plasma membrane • integral to membrane Biological process • lipid metabolic process • sphingolipid metabolic process • ceramide metabolic process • apoptosis • signal transduction Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56624	54447
Ensembl	ENSG00000188611	ENSMUSG00000024887
UniProt	Q9NR71	Q9JHE3
RefSeq (mRNA)	NM_001143974.1	NM_018830.1
RefSeq (protein)	NP_001137446.1	NP_061300.1
Location (UCSC)	Chr 10: 51.88 – 52.04 Mb	Chr 19: 32.06 – 32.14 Mb
PubMed search	[1]	[2]

Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene.^[1][2]

References

1. ^ El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA (Aug 2000). "Molecular cloning and characterization of a human mitochondrial ceramidase". J Biol Chem 275 (28): 21508–13. doi:10.1074/jbc.M002522200. PMID 10781606. 
2. ^ "Entrez Gene: ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56624. 

Further reading

• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819. 
• Tani M, Okino N, Mori K, et al. (2000). "Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases.". J. Biol. Chem. 275 (15): 11229–34. doi:10.1074/jbc.275.15.11229. PMID 10753931. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Choi MS, Anderson MA, Zhang Z, et al. (2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.". Gene 315: 113–22. doi:10.1016/S0378-1119(03)00721-2. PMID 14557071. 
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
• Monick MM, Mallampalli RK, Bradford M, et al. (2004). "Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity.". J. Immunol. 173 (1): 123–35. PMID 15210766. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Hwang YH, Tani M, Nakagawa T, et al. (2005). "Subcellular localization of human neutral ceramidase expressed in HEK293 cells.". Biochem. Biophys. Res. Commun. 331 (1): 37–42. doi:10.1016/j.bbrc.2005.03.134. PMID 15845354. 
• Osawa Y, Uchinami H, Bielawski J, et al. (2005). "Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.". J. Biol. Chem. 280 (30): 27879–87. doi:10.1074/jbc.M503002200. PMID 15946935. 
• Tani M, Sano T, Ito M, Igarashi Y (2006). "Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets.". J. Lipid Res. 46 (11): 2458–67. doi:10.1194/jlr.M500268-JLR200. PMID 16061940. 
• Galadari S, Wu BX, Mao C, et al. (2006). "Identification of a novel amidase motif in neutral ceramidase.". Biochem. J. 393 (Pt 3): 687–95. doi:10.1042/BJ20050682. PMC 1360721. PMID 16229686. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1360721. 
• Xu R, Jin J, Hu W, et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P.". FASEB J. 20 (11): 1813–25. doi:10.1096/fj.05-5689com. PMID 16940153. 
• Avramopoulos D, Wang R, Valle D, et al. (2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease.". Neurogenetics 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805. 
• Ohlsson L, Palmberg C, Duan RD, et al. (2007). "Purification and characterization of human intestinal neutral ceramidase.". Biochimie 89 (8): 950–60. doi:10.1016/j.biochi.2007.03.009. PMID 17475390. 

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