ASAH2C
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ASAH2C
| N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2C | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | ASAH2C | ||||||||||
| External IDs | HomoloGene: 121147 GeneCards: ASAH2C Gene | ||||||||||
| EC number | 3.5.1.23 | ||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 653365 | n/a | |||||||||
| Ensembl | ENSG00000072444 | n/a | |||||||||
| UniProt | P0C7U2 | n/a | |||||||||
| RefSeq (mRNA) | XM_927086 | n/a | |||||||||
| RefSeq (protein) | XP_932179 | n/a | |||||||||
| Location (UCSC) | Chr 10: 47.52 – 47.53 Mb |
n/a | |||||||||
| PubMed search | [1] | n/a | |||||||||
Neutral ceramidase C also known as N-acylsphingosine amidohydrolase 2C or non-lysosomal ceramidase C or ASAH2C is a ceramidase enzyme which in humans is encoded by the ASAH2C gene.[1]
References
- ^ Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805.
Further reading
- Choi MS, Anderson MA, Zhang Z, et al. (2003). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.". Gene 315: 113–22. doi:10.1016/S0378-1119(03)00721-2. PMID 14557071.
- El Bawab S, Roddy P, Qian T, et al. (2000). "Molecular cloning and characterization of a human mitochondrial ceramidase.". J. Biol. Chem. 275 (28): 21508–13. doi:10.1074/jbc.M002522200. PMID 10781606.
- Tani M, Sano T, Ito M, Igarashi Y (2005). "Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets.". J. Lipid Res. 46 (11): 2458–67. doi:10.1194/jlr.M500268-JLR200. PMID 16061940.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Galadari S, Wu BX, Mao C, et al. (2006). "Identification of a novel amidase motif in neutral ceramidase.". Biochem. J. 393 (Pt 3): 687–95. doi:10.1042/BJ20050682. PMC 1360721. PMID 16229686. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1360721.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Hwang YH, Tani M, Nakagawa T, et al. (2005). "Subcellular localization of human neutral ceramidase expressed in HEK293 cells.". Biochem. Biophys. Res. Commun. 331 (1): 37–42. doi:10.1016/j.bbrc.2005.03.134. PMID 15845354.
- Osawa Y, Uchinami H, Bielawski J, et al. (2005). "Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.". J. Biol. Chem. 280 (30): 27879–87. doi:10.1074/jbc.M503002200. PMID 15946935.
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