Asoprisnil

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Asoprisnil

Systematic (IUPAC) name
rel-4-[(8R,11S,13R,14R,17R)-17-Methoxy-17-
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	199396-76-4^N
ATC code	None
PubChem	CID 9577221
IUPHAR ligand	2883
ChemSpider	7851660^Y
UNII	72W09924WP^Y
KEGG	D02996^Y
ChEMBL	CHEMBL267431^Y
Chemical data
Formula	C₂₈H₃₅N O₄
Mol. mass	449.582 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,16,23-25,31H,8-13,15,17H2,1-3H3/b29-16+/t23-,24+,25-,27-,28+/m0/s1^Y Key:GJMNAFGEUJBOCE-MEQIQULJSA-N^Y
N (what is this?) (verify)

Asoprisnil (J867) is an investigational selective progesterone receptor modulator developed by Schering and TAP Pharmaceutical Products, tested for treatment of progesterone sensitive myomata.^[1]

In 2005, Phase III trials were discontinued due to endometrial changes in patients. It is uncertain whether asoprisnil will be marketed.^[2]

References

^ DeManno D, Elger W, Garg R, et al. (2003). "Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy". Steroids 68 (10-13): 1019–32. doi:10.1016/j.steroids.2003.09.008. PMID 14667995.
^ Schering Interim Report Q1-3 2005

Progestogenics

Receptor

PR (A, B)

Agonists: 11-Dehydroprogesterone
11-Deoxycorticosterone
17-Hydroxyprogesterone
19-Norprogesterone
Algestone
Algestone acetonide
Algestone acetophenide
Allylestrenol
Altrenogest
Amadinone
Amadinone acetate
Anagestone
Anagestone acetate
Chlormadinone
Chlormadinone acetate
Cingestol
Cismadinone
Cismadinone acetate
Clogestone
Clogestone acetate
Clomegestone
Cyproterone
Cyproterone acetate
Delmadinone
Delmadinone acetate
Demegestone
Desogestrel
Dienogest
Dimethisterone
Drospirenone
Dydrogesterone
Edogesterone
Ethisterone
Ethynerone
Ethynodiol diacetate
Etonogestrel
Etynodiol
Flugestone
Flugestone acetate
Gestaclone
Gestadienol
Gestodene
Gestonorone
Gestonorone caproate
Gestovister
Gestrinone
Gestronol
Haloprogesterone
Hydromadinone
Hydroxyprogesterone acetate
Hydroxyprogesterone caproate
Hydroxyprogesterone heptanoate
Hydroxyprogesterone hexanoate
Levonorgestrel
Lutenyl
Lynestrenol
Medrogestone
Medroxyprogesterone
Medroxyprogesterone acetate
Megestrol
Megestrol acetate
Melengestrol
Melengestrol acetate
Methylestrenolone
Methynodiol
Methynodiol diacetate
Metogest
Nandrolone
Nomegestrol
Norelgestromin
Norethisterone/Norethindrone
Norethisterone acetate
Norethisterone acetate oxime
Norethisterone enanthate
Norethynodrel
Norgesterone
Norgestimate
Norgestomet
Norgestrel
Norgestrienone
Norvinisterone
Org-2058
Oxogestone
Oxogestone phenpropionate
Pentagestrone
Progesterone
Proligestone
Promegestone
Quingestanol
Quingestanol acetate
Quingestrone
Segesterone
Spironenone
Tibolone
Tigestol
Tosagestin
Trengestone
Trimegestone
ZM-182,345

Mixed (SPRMs): Asoprisnil
Asoprisnil ecamate
J1042
LG-120,838
Telapristone; Antagonistic:
Mifepristone
Org-31710
Org-33628
Ulipristal acetate
ZK-137,316
ZK-230,211

Antagonists: Aglepristone
Lilopristone
Lonaprisan
Onapristone
Toripristone
ZM-150,271
ZM-172,406

Enzyme
(inhibitors)

20,22-Desmolase	22-ABC 3,3′-Dimethoxybenzidine 3-Methoxybenzidine Aminoglutethimide Cyanoketone Danazol Etomidate Trilostane

17α-Hydroxylase, 17,20-Lyase	22-ABC 22-Oxime Abiraterone Bifonazole Clotrimazole Cyanoketone Cyproterone Danazol Desogestrel Econazole Galeterone Gestrinone Isoconazole Ketoconazole L-39 Levonorgestrel Liarozole LY-207,320 MDL-27,302 Miconazole Mifepristone Norethisterone Orteronel Pioglitazone Rosiglitazone Spironolactone Stanozolol SU-10,603 Tioconazole TGF-β Troglitazone VN/87-1 YM116

3β-HSD	4-MA Azastene Cyanoketone Danazol Desogestrel Epostane Genistein Gestrinone Levonorgestrel Medroxyprogesterone Medroxyprogesterone acetate Metyrapone Norethisterone Oxymetholone Pioglitazone Rosiglitazone Trilostane Troglitazone

21-Hydroxylase	Aminoglutethimide Amphenone B Bifonazole Clotrimazole Diazepam Econazole Genistein Isoconazole Ketoconazole Metyrapone Miconazole Midazolam Tioconazole

Other

Precursors	Cholesterol 22R-Hydroxycholesterol 20α,22R-Dihydroxycholesterol Pregnenolone 17-Hydroxypregnenolone 17-Hydroxyprogesterone

Indirect	Androgens/Antiandrogens (see here) Estrogens/Antiestrogens (see here) GnRH agonists/antagonists (see here) Gonadotropins (see here) Plasma proteins (Transcortin, Albumin)

Procedures	Adrenalectomy Hypophysectomy Oophorectomy Orchiectomy

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