Asoxime chloride

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Asoxime chloride

Systematic (IUPAC) name
4-carbamoyl-1-[({2-[(E)-(hydroxyimino)methyl]pyridinium-1-yl}methoxy)methyl]pyridinium dichloride
Clinical data
Pregnancy cat.	?
Legal status	Experimental
Routes	Intramuscular injection
Identifiers
CAS number	34433-31-3^N
ATC code	?
PubChem	CID 5484128
ChemSpider	13004322^Y
ChEMBL	CHEMBL33051^Y
Chemical data
Formula	C₁₄H₁₆Cl₂N₄O₃
Mol. mass	359.21 g/mol
InChI InChI=1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H^Y Key:QELSIJXWEROXOE-UHFFFAOYSA-N^Y
N(what is this?) (verify)

Asoxime chloride, or more commonly HI-6, is a Hagedorn oxime used in the treatment of organophosphate poisoning.

Antidotes (V03AB)

Nervous system


Nerve agent / Organophosphate poisoning	Atropine^# • Biperiden • Diazepam^# • Oximes (Pralidoxime, Obidoxime) • see also Cholinesterase

Opioid overdose	Diprenorphine • Doxapram • Nalorphine • Naloxone^# • Naltrexone • Nalmefene

Barbiturate overdose	Bemegride • Ethamivan

Benzodiazepine overdose	Cyprodenate • Flumazenil

GHB overdose	Physostigmine • SCH-50911

Reversal of neuromuscular blockade	Sugammadex

Cardiovascular

Heparin	Protamine^#

Digoxin toxicity	Digoxin Immune Fab

Beta blocker	Glucagon

Other

Methanol / Ethylene glycol poisoning	Ethanol • Fomepizole

Paracetamol toxicity (Acetaminophen)	Acetylcysteine^# • Glutathione • Methionine^#

Arsenic poisoning	Dimercaprol^# • Succimer

Cyanide poisoning	nitrite (Amyl nitrite, Sodium nitrite^#) • Sodium thiosulfate^# • 4-Dimethylaminophenol • Hydroxocobalamin

Toxic metals (cadmium, mercury, lead, thallium)	Edetates • Dimercaprol^# • Prussian blue^#

Hydrofluoric acid	Calcium gluconate^#

Other	Prednisolone/promethazine • oxidizing agent (potassium permanganate) • iodine-131 (Potassium iodide) • Methylthioninium chloride^#

Emetic

Ipecacuanha (Syrup of ipecac) • Copper sulfate

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

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