Atosiban
Oxford A-Z of Medicinal Drugs:
Top
atosiban
A drug used to prevent premature labour in women who are 24–33 weeks pregnant. It works by blocking the action of oxytocin, which causes contractions of the uterus. Atosiban is given by intravenous injection and infusion and is available on prescription only.
Side effects:
include headache, dizziness, nausea, vomiting, low blood pressure, and an increased heart rate.
Precautions:
atosiban should be used with caution in women with liver or kidney disease.
Proprietary preparation:
Tractocile.
| atorvastatin, atomoxetine, atherosclerosis | |
| atovaquone, atropine sulphate, attapulgite |
Wikipedia on Answers.com:
Top
Atosiban
 |
|
|---|---|
| Systematic (IUPAC) name | |
| 1-(3-mercaptopropanoic acid)- 2-(O-ethyl-D-tyrosine)-4-L-threonine- 8-L-ornithine-oxytocin |
|
| Clinical data | |
| Trade names | Tractocile, Antocin |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | intravenous |
| Identifiers | |
| CAS number | 90779-69-4  |
| ATC code | G02CX01 |
| PubChem | CID 5311010 |
| ChemSpider | 4470550  |
| UNII | 081D12SI0Z |
| KEGG | D03008 |
| ChEMBL | CHEMBL378642 |
| Chemical data | |
| Formula | C43H67N11O12S2 |
| Mol. mass | 994.199 |
| SMILES | eMolecules & PubChem |
|
|
 (what is this?) (verify) |
|
Atosiban (trade names Tractocile, Antocin) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. It was developed by Ferring Pharmaceuticals in Sweden and first reported in the literature in 1985.[1]
Chemically, it is a modified form of oxytocin that inhibits the action of this hormone on the uterus, leading to a cessation of contractions.
A 2005 systematic review by the Cochrane Collaboration showed that while atosiban had fewer side-effects than alternative drugs (such as ritodrine), it was no better than placebo in the major outcomes, and in one study showed worse neonatal outcomes. The reviewers suggest nifedipine may be more promising.[2]
See also
References
- ^ Akerlund M, Carlsson AM, Melin P, Trojnar J (1985). "The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin". Acta Obstet Gynecol Scand. 64 (6): 499–504. doi:10.3109/00016348509156728. PMID 4061066.
- ^ Papatsonis D, Flenady V, Cole S, Liley H (2005). Papatsonis, Dimitri. ed. "Oxytocin receptor antagonists for inhibiting preterm labour". Cochrane database of systematic reviews (Online) (3): CD004452. doi:10.1002/14651858.CD004452.pub2. PMID 16034931.
|
||||||||||||||||||||||
 |
This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it. |
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Post a question - any question - to the WikiAnswers community:
Copyrights:
Oxford A-Z of Medicinal Drugs
Market University Press. © 2000, 2003, 2010 An A-Z of Medicinal Drugs. All rights reserved.
Read more
