biologically active peptides isolated from mammalian cardiac atria. Atriopeptin I (I) has 21 amino acids, with the structure SSCFGGRIDRIGAQSGLGCNS 3 — 19 disulfide link); atriopeptin II (II) is the same with additional Phe-Arg residues at the C terminus; atriopeptin III is the same as II but with an additional Tyr residue at the C terminus. I relaxes intestinal smooth muscle but not vascular smooth muscle, while II relaxes both. Compare natriuretic peptide.